Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Szent-Gyorgyi

The molecular events of contraction are powered by the ATPase activity of myosin. Much of our present understanding of this reaction and its dependence on actin can be traced to several key discoveries by Albert Szent-Gyorgyi at the University of Szeged in Hungary in the early 1940s. Szent-Gyorgyi showed that solution viscosity is dramatically increased when solutions of myosin and actin are mixed. Increased viscosity is a manifestation of the formation of an actomyosin complex. [Pg.551]

Szent-Gyorgyi further showed that the viscosity of an actomyosin solution was lowered by the addition of ATP, indicating that ATP decreases myosin s affinity for actin. Kinetic studies demonstrated that myosin ATPase activity was increased substantially by actin. (For this reason, Szent-Gyorgyi gave the name actin to the thin filament protein.) The ATPase turnover number of pure myosin is 0.05/sec. In the presence of actin, however, the turnover number increases to about 10/sec, a number more like that of intact muscle fibers. [Pg.552]

Goldberger and Lillie in 1926 found that rats fed certain nutritionally deficient diets developed dermatitis acrodynia, a skin disorder characterized by edema and lesions of the ears, paws, nose, and tail. Szent-Gyorgyi later found that a factor he had isolated prevented these skin lesions in the rat. He proposed the name vitamin Bg for his factor. Pyridoxine, a form of this vitamin found in plants (and the form of Bg sold commercially), was isolated in 1938 by three research groups working independendy. Pyridoxal and pyridoxamine, the forms that predominate in animals, were... [Pg.597]

The isolation of ascorbic acid was first reported by Albert Szent-Gyorgyi (who called it hexuronie add) in 1928. The structure was determined by ITirst and Haworth in 1933, and, simultaneously, Reichstein reported its synthesis. Haworth and Szent-Gyorgyi, who together suggested that the name be changed to L-ascorbic acid to describe its antiscorbutic (antiscnrvy) activity, were awarded the Nobel Prize in 1937 for their studies of vitamin C. [Pg.600]

Another important piece of the puzzle came from the work of Carl Martius and Franz Knoop, who showed that citric acid could be converted to isocitrate and then to a-ketoglutarate. This finding was significant because it was already known that a-ketoglutarate could be enzymatically oxidized to succinate. At this juncture, the pathway from citrate to oxaloacetate seemed to be as shown in Figure 20.3. Whereas the pathway made sense, the catalytic effect of succinate and the other dicarboxylic acids from Szent-Gyorgyi s studies remained a puzzle. [Pg.642]

G. Vasaru, D. Ursu, a. MihAila and P. Szent-Gyorgyi, Deuterium and Heavy Water, Elsevier, Amsterdam, 1975, 404 pp. [Pg.40]

Ballou, B., Szent-Gyorgyi, C., and Finley, G. (2000). Properties of a new luciferase from the copepod Gaussia princeps. 11th Int. Symp. on Biolumin. Chemilumin., Abstract p. 34. Asilomar, CA. [Pg.382]

RE Sohn, KL Vikstrom, M Strauss, C Cohen, AG Szent-Gyorgyi, LA Leinward. J Mol Biol... [Pg.470]

Drury, A. N. Szent-Gyorgyi, A. (1929). The physiological activity of adenine compounds with special reference to their action upon mammalian heart. [Pg.49]

Ascorbic acid, which is closely related to the sugars and is no doubt derived from them in the metabolism of the cells of plants, has been shown to be identical with vitamin- C (Szent-Gyorgyi). It has the constitution of a lactone of a-keto-i-gulonic acid (W. N. Haworth, T. Reichstein) ... [Pg.400]

Institute of Pharmaceutical Chemistry, Albert Szent-Gyorgyi Medical University, H-6720, Szeged, POB 121, Hungary... [Pg.251]

Szent-Gyorgyi A (1941) Towards anew biochemistry Science 93 609-611... [Pg.113]

A. Szent-Gyorgyi (1960). Introduction to Submolecular Biology. New York Academic Press. [Pg.64]

Hauptmann accidentally discovers barbiturates as anticonvulsants (see 1903, 1882) Loewi demonstrates that acetylcholine is a neurotransmitter Banting and Best purify insulin as treatment for diabetes Szent-Gyorgyi isolates ascorbic acid (Vitamin C)... [Pg.110]

In 1795 the British admiralty finally mandated a ration of concentrated lime or lemon juice for all British sailors (hence the name limeys ). Scurvy continued to be a problem in some other parts of the world until 1932, when Hungarian scientist Albert Szent-Gyorgyi, and W. A. Waugh and C. G. King at the University of Pittsburgh, isolated and synthesized ascorbic acid. [Pg.131]


See other pages where Szent-Gyorgyi is mentioned: [Pg.7]    [Pg.223]    [Pg.551]    [Pg.641]    [Pg.209]    [Pg.231]    [Pg.366]    [Pg.300]    [Pg.44]    [Pg.498]    [Pg.519]    [Pg.306]    [Pg.918]    [Pg.53]    [Pg.197]    [Pg.209]    [Pg.232]    [Pg.186]    [Pg.103]    [Pg.103]    [Pg.352]    [Pg.159]    [Pg.248]    [Pg.3]    [Pg.31]    [Pg.487]    [Pg.628]    [Pg.58]   
See also in sourсe #XX -- [ Pg.197 , Pg.209 , Pg.232 ]

See also in sourсe #XX -- [ Pg.623 , Pg.624 , Pg.631 ]

See also in sourсe #XX -- [ Pg.143 , Pg.151 , Pg.251 ]

See also in sourсe #XX -- [ Pg.32 , Pg.448 ]

See also in sourсe #XX -- [ Pg.395 ]

See also in sourсe #XX -- [ Pg.116 , Pg.131 ]




SEARCH



Gyorgyi

Szent-Gyorgyi Albert

Szent-Gyorgyi cycle

© 2024 chempedia.info