Addition-elimination mechanism of nucleophilic

The Addition-Elimination Mechanism of Nucleophilic Aromatic Substitution... [Pg.977]

THE ADDITION-ELIMINATION MECHANISM OF NUCLEOPHILIC AROMATIC SUBSTITUTION... [Pg.977]

The reaction of benzenesulfomc acid with sodium hydroxide (first entry m Table 24 3) proceeds by the addition-elimination mechanism of nucleophilic aromatic substi... [Pg.1000]

The reaction of benzenesulfonic acid with sodium hydroxide (first entry in Table 24.3) proceeds by the addition-elimination mechanism of nucleophilic aromatic substitution (Section 23.6). Hydroxide replaces sulfite ion (S03 ) at the carbon atom that bear s the leaving group. Thus, p-toluenesulfonic acid is converted exclusively to p-cresol by an analogous reaction ... [Pg.1000]

Scheme 47. The addition-elimination mechanism of nucleophilic aromatic fluorination in the pyridine series.

Key Mechanism 21-1 Addition-Elimination Mechanism of Nucleophilic Acyl Substitution 998 Mechanism 21-2 Conversion of an Acid Chloride to an Anhydride 1001... [Pg.19]

Ammonia and amines react with acid chlorides to give amides, also through the addition-elimination mechanism of nucleophilic acyl substitution. A carboxylic acid is efficiently converted to an amide by forming the acid chloride, which reacts with an amine to give the amide. A base such as pyridine or NaOH is often added to prevent HC1 from protonating the amine. [Pg.971]

As we study these conversions of acid derivatives, it may seem that many individual mechanisms are involved. But all these mechanisms are variations on a single theme the addition-elimination mechanism of nucleophilic acyl substitution (Key Mechanism 21-1). These reactions differ only in the nature of the nucleophile, the leaving group, and proton transfers needed before or after the actual substitution. As we study these mechanisms, watch for these differences and don t feel that you must learn each specific mechanism. [Pg.1000]

The reaction between an alkoxide ion and an aryl halide can be used to prepare alkyl aryl ethers only when the aryl halide is one that reacts rapidly by the addition-elimination mechanism of nucleophilic aromatic substitution (Section 12.21). [Pg.1003]

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