Microvascular adaptation

Fig. 6. (a) Interstitial pressure gradients in the mammary adenocarcinoma R3230AC as a function of radial position. The circles ( ) represent data points (Boucher et al., 1990), and the solid line represents the theoretical profile based on our previously developed mathematical model (Jain and Baxter, 1988 Baxter and Jain, 1989). Note that the pressure is nearly uniform in most of the tumor, but drops precipitously to normal tissue values in the periphery. Elevated pressure in the central region retards the extravasation of fluid and macromolecules. In addition, the pressure drop from the center to the periphery leads to an experimentally verifiable, radially outward fluid flow. (Reproduced from Boucher et al., 1990, with permission.) (b) Microvascular pressure (MVP) in the peripheral vessels of the mammary adenocarcinoma R3230AC is comparable to the central interstitial fluid pressure (IFP) (adapted from Boucher and Jain, 1992). These results suggest that osmotic pressure difference across vessel walls is small in this tumor. 

Fig. 6 Examples of vessel-on-a-chip platform. (A) Schematic of two PDMS chamber connected by a membrane and (B) the image of fabricated device (Adapted from [63]). (C) Long microfluidic channel with a consecutive flow and (D) repeatedly stretched and relaxed elastic membrane (Adapted from [64]). (E) Three-dimensional perfusable tubular capillary network in a microfluidic platform (Adapted from [65]). (F) Microvasculare network on a chip filled with fibrin gel inside the main channel (Adapted from [66]).

Brain Microvascular and Metabolic Adaptation to Proionged Mild Hypoxia... 

The microcirculation is adapted to a specific distribution of oxygen tension (pOj) that is in part determined by the shape of the oxygen dissociation curve for hemoglobin. In this system, blood with specific pOj locates at specific microvascular sites as a result of the control of active mechanisms that sense pOj in tissue and blood, and partition oxygen delivery between the arteriolar and capillary circulation [44]. 

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