Adapalene

Molecular formula C28H28O3 Molecular weight 412.52 CAS Registry No 106685-40-9 Merck Index 13,150 

Mobile phase MeCN THF water trifluoroacetic acid 43 36 21 0.02 Flow rate 1 Detector UV 270 

Martin, B. Meunier, C. Montels, D. Watts, O. Chemical stability of adapalene and tretinoin when combined with benzoyl peroxide in presence and in absence of visible light and ultraviolet radiation, Br.J.Derrnatol., 1998,139 (Suppl. 52), 8-11. 

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R. Ruhl and H. Nau, Deteimination of adapalene (CD271/Differin ) and retinol in plasma and tissue by on-line solid-phase exti action and HPEC analysis , Chro-matographia 45 269-274 (1997). 

Adapalene (Table 1), a new highly stable naphtoic acid arotinoid with lipophilic properties, does not bind to CRABP, although it enhances its synthesis, and its rank-order of retinoid receptor affinity apears to be RAR(3 > RARy > > RARa. 

Jacyk WK, Mpofu P (2001) Adapalene gel 0.1% for topical treatment of acne vulgaris in African patients. Cutis 68 48-54... 

Retinoids, which are highly effective in the treatment of acne, stimulate epithelial cell turnover and aid in unclogging blocked pores. Retinoids also exhibit anti-inflammatory properties through the inhibition of neutrophil and monocyte chemotaxis.8 Because of these comedolytic and antiinflammatory effects, topical retinoids are recommended as first-line treatment for mild to moderate comedonal and inflammatory acne.3 While success is seen with monotherapy, using a retinoid in combination with benzoyl peroxide or topical antibacterials is also an appropriate and effective therapeutic treatment option.3 Tretinoin, adapalene, and tazarotene are topical retinoids available for use in the treatment of acne. Table 62-2 describes the strengths and formulations of these agents. 

Adapalene Differin 0.1% cream 0.1% gel Apply a small amount once daily before bedtime Same as tretinoin but may be less severe... 

Adapalene (Differin) is a third-generation retinoid with comedolytic, kera-tolytic, and antiinflammatory activity, ft is available as 0.1% gel, cream, alcoholic solution, and pledgets. A 0.3% gel formulation is also available. 

Adapalene is indicated for mild to moderate acne vulgaris. The 0.1% gel can be used as an alternative to tretinoin 0.025% gel to achieve better tolerability in some patients. 

Adams-Nickerson color space, 7 320 Adapalene, 25 789 Adapress, molecular formula and structure, 5 128t Adaptive control system, 20 698 Adaptive sampling techniques, 26 1016-1019... 

Not infrequently, retinol is used for mild acne, and the more active retinoids such as retinoic acid, isotretinoin, and adapalene serve for the treatment of the more severe forms. Retinol incorporated into Compritol-based SLN has been released more rapidly and to a higher extent compared with conventional vehicles and with a ) 2005 by CRC Press LLC... 

Retinoic acid, adapalene, isotretinoin (ADAFERIN), benzoyl peroxide, azelaic acid... 

Adapalene is a napthoic acid derivative with retinoid-like activity used for the topical treatment of acne vulgaris. Adverse effects include erythema, dryness of skin and skin irritation. 

Adapalene (Differin) is a derivative of naphthoic acid that resembles retinoic acid in structure and effects. It is applied as a 0.1% gel once daily. Unlike tretinoin, adapalene is photochemically stable and shows little decrease in efficacy when used in combination with benzoyl peroxide. Adapalene is less irritating than tretinoin and is most effective in patients with mild to moderate acnevulgaris. 

Topical treatment of acne vulgaris Adapalene Differin Carbomer 940/sodium hydroxide Aqueous... 

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