Acylphenoxyacetic acids

Recently, a high order of diuretic activity in dogs and in man has been found in a series of unsaturated acylphenoxyacetic acids (55). Of this series, ethacrynic acid has been most extensively studied. The effective daily clinical... 

Use as a Base in Condensation Reactions. Pyridine can be used as a base in cyclocondensation reactions. When the reaction of 2-acylphenoxyacetic acids in acetic anhydride is carried out in the presence of pyridine, formation of benzofuran-2-carboxylic acids is preferred. When weaker bases such as sodium acetate or sodium formate are used for the reaction, mixtures of ben-zofurans and benzofuran-2-carboxyhc acids are produced, with... 

---