Acylphenoxyacetates

Sharshira, E.M. and Horaguchi, T. (1997) Photocyclization reactions. Part 7 [1]. Solvent and substituent effects in the synthesis of dihydrobenzofuranols using photocyclization of a-(2-acylphenoxy) toluenes and ethyl 2-acylphenoxyacetates. Journal of Heterocyclic Chemistry, 34, 1837-1848. 

Recently, a high order of diuretic activity in dogs and in man has been found in a series of unsaturated acylphenoxyacetic acids (55). Of this series, ethacrynic acid has been most extensively studied. The effective daily clinical... 

Use as a Base in Condensation Reactions. Pyridine can be used as a base in cyclocondensation reactions. When the reaction of 2-acylphenoxyacetic acids in acetic anhydride is carried out in the presence of pyridine, formation of benzofuran-2-carboxylic acids is preferred. When weaker bases such as sodium acetate or sodium formate are used for the reaction, mixtures of ben-zofurans and benzofuran-2-carboxyhc acids are produced, with... 

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