Acute renal failure gentamicin

Bll. Bulger, R. E., Eknoyan, G., Purcell, D. J., and Dobyan, D. C., Endothehal characteristic of glomerular capillaries in normal, mercuric-chloride-induced, and gentamicin-induced acute renal failure in the rat. J. Clin. Invest. 72, 128-141 (1983). 

Nakakuki M, Yamasaki F, Shinkawa T, Kudo M, Watanabe M, Mizota M. Protective effect of human ulinastatin against gentamicin-induced acute renal failure in rats. Can J Physiol Pharmacol 1996 74 104-111. 

Neugarten J, Aynedjian HS, Bank N Role of tubular obstruction in acute renal failure due to gentamicin. Kidney Int 24 330-335, 1983... 

Walker PD, ShavSV, Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats, J Clin Invest, 1988,81 334-41. 

Teixeira RB, Kelley J, Alpert El, Pardo V, Vaamonde CA. Complete protection from gentamicin-induced acute renal failure in the diabetes mellitus rat. Kidney Int 1982 21 600-612. 

A study assessing the risk factors for nephrotoxicity with aminoglycosides (tobramycin and gentamicin) enrolled 1489 patients, 157 of whom developed clinical nephrotoxicity. Of these patients 118 had no immediately identifiable cause (sueh as acute renal failure) and further evaluation of other risk factors found that the concurrent use of amphotericin B significantly increased the risk of nephrotoxicity. ... 

Kleinknecht D, Ganeval D, Droz D. Acute renal failure after high doses of gentamicin and cephalotiiin. Lancet (1973) i, 1129. 

Fillaslre JP, Laumonier R, Humbert G, Dubois D, Metayer J, Delpech A, Leroy J, RobertM Acute renal failure associated witii combined gentamicin and cephalotiiin therq. EMJ (1973) 2, 396-7. 

Tvedegaard E. Interaction between gentamicin and cephalotiiin as cause of acute renal failure. Lancet ( 91 ) ii, 581. 

Three cases of acute renal failure have been tentatively attributed to the use of gentamicin with clindamycin, and another report identified the combination as a risk factor for nephrotoxicity. However, other reports note no increased nephrotoxicity when gentamicin or tobramycin was given with clindamycin. 

Acute renal failure has been reported in 3 patients with normal renal function when they were given gentamicin 3.9 to 4.9 mg/kg daily and clindamycin 0.9 to 1.8 mg/kg daily for 13 to 18 days. They recovered within 3 to 5 days of discontinuing the antibacterials but in one patient acute renal failure only developed after the clindamycin was stopped. The reasons for the renal failure are not known, but given the long courses of gen-... 

Weibert RT, Keane WF Carbenicillin-gentamicin interaction in acute renal failure. AmJ HospPharm 9TI) 34, IB7-9... 

The incidence of acute renal failure appears to be increased in cardiac sui ical patients given polygeline (Haemaccel) with gentamicin. 

Schneider M, Valentine S, Clarke GM, Newman MAJ, Peakcock J. Acute renal failure in cardiac surgical patients potentiated by gentamicin and calcium. Anaesth Intensive Care (1996) 24, 647-50,... 

Gonzalez-Vitale JC, I es DM, Cvitkovic E, Stembei SS. Acute renal failure after m-Dichlorodiammineplatiinim ( ) and gentamicin-cephalothin therapies. Cancer Treat Rep (1978) 62,693-8. 

In Japan, tobramycin has been studied in many hospitals. Among the records of 236 patients there has been one case of acute renal failure, and 2 cases of temporarily increased urea in the blood (26 ). In a comparative study in Belgium of the clinical effectiveness of tobramycin and gentamicin, azotaemia developed in 1 patient out of 31 receiving tobramycin, and in 2 of the 31 patients treated with gentamicin. Both antibiotics showed the same degree of effectiveness (27 ). 

---