Acute generalised exanthematous pustulosis

Pennisi, R.S. 2006. Acute generalised exanthematous pustulosis induced by the herbal remedy Ginkgo biloba. Med.. Aust. 184(ll) 583-584. 

Hammerbeck AA, Daniels NH, Callan JP. loversol induced acute generalised exanthematous pustulosis. Arch Dermatol 2009 145 683-7. 

Skin A case of a 53-year-old female who developed acute generalised exanthematous pustulosis 7days after starting treatment with quetiapine is reported [230 ]. 

HCTZ = hydrochlorothiazide, ACG = angle-closure glaucoma, AGEP = acute generalised exanthematous pustulosis, SPED=serous pigment epithelial detachment, SRD = serous retinal detachment. 

A 47-year-old man with a history of rash to cephalexin was treated for erysipelas with clindamycin. His condition did not improve on clindamycin, so it was discontinued and he was initiated on ertapenem. After 2 days of ertapenem treatment, he developed fever, a generalised rash and neufrophilia of 28 x fi cells/L (7.1 x 10 cells/L the day before). All other laboratory values, cultures and chest X-rays were normal. He was diagnosed with acute generalised exanthematous pustulosis (AGEP). Patch tests were posihve for penicillin, cephalothin, meropenem and ertapenem at 48 h. Per the autiiors, this was the first reported cause of carbapenem-induced AGEP confirmed by patch testing [79 ]. 

A single case of a 56-year-old woman developing acute generalised exanthematous pustulosis following 1 g three times per day of pristinamycin was reported [138 ]. 

Catho G, Ader F, Chidiac C, Ferry T. Acute generalised exanthematous pustulosis due to pristinamycin. BMJ Case Rep 2013 2013. 

Skin Several cases of acute generalised exanthematous pustulosis (AGEP) have been attributed to terbinafine [2, 3 ]. 

Acute generalised exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction, mostly drug related or associated with viral infections. It can also manifest as a reaction to dapsone therapy in the setting of HTV infection when used as prophylaxis for pneumocystis jirovecii pneumonia [75 ]. 

Vas A, Laws P, Marsland A, McQuillan O. Acute generalised exanthematous pustulosis induced by Pneumocystis jimvecii pneiunonia prophylaxis with dapsone. Int J STD AIDS 2013 24(9) 745-7. 

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