Acute generalised exanthematous pustulosis AGEP

A 47-year-old man with a history of rash to cephalexin was treated for erysipelas with clindamycin. His condition did not improve on clindamycin, so it was discontinued and he was initiated on ertapenem. After 2 days of ertapenem treatment, he developed fever, a generalised rash and neufrophilia of 28 x fi cells/L (7.1 x 10 cells/L the day before). All other laboratory values, cultures and chest X-rays were normal. He was diagnosed with acute generalised exanthematous pustulosis (AGEP). Patch tests were posihve for penicillin, cephalothin, meropenem and ertapenem at 48 h. Per the autiiors, this was the first reported cause of carbapenem-induced AGEP confirmed by patch testing [79 ]. 

Skin Several cases of acute generalised exanthematous pustulosis (AGEP) have been attributed to terbinafine [2, 3 ]. 

Acute generalised exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction, mostly drug related or associated with viral infections. It can also manifest as a reaction to dapsone therapy in the setting of HTV infection when used as prophylaxis for pneumocystis jirovecii pneumonia [75 ]. 

HCTZ = hydrochlorothiazide, ACG = angle-closure glaucoma, AGEP = acute generalised exanthematous pustulosis, SPED=serous pigment epithelial detachment, SRD = serous retinal detachment. 

---

See also in sourсe #XX -- [ , , ]

---