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Activity against A549 human

The cytotoxic activities both in vitro and in vivo of lusianthridin and denbinobin isolated from Dendrobium nobile are evaluated. Both of them exhibit potent antitumor effects against A549 human lung carcinoma, SK-OV-3 human ovary adenocarcinoma, and HL-60 human promyelocytic leukemia with EC50 values ranging from 0.11 to 9.8 pg/mL [124]. [Pg.1934]

Recently, our laboratory designed and synthesized several series of new water-soluble phenanthrene-based tylophorine derivatives (PBTs) as potential antitumor agents. These compounds contain a core phenanthrene structure and can be synthesized efficiently in excellent yield. The newly synthesized PBTs were evaluated for cytotoxic activity against the A549 human cancer cell line. Among them, V-(2,3-methylenedioxy-6-methoxy-phenanthr-9-ylmethyl)-L-2-piperidinemethanol (100) and /V- (2,3 - methyl enedioxy - 6- meth oxy-... [Pg.24]

Special mention must be made of the isolation of madangamine (104). This compound is of interest because of its unique structure and the fact that it shows significant in vitro cytotoxic activity against a number of tumor cell lines, including human lung A549, brain U373, and breast MCF-7 [112],... [Pg.648]

See other pages where Activity against A549 human is mentioned: [Pg.458]    [Pg.245]    [Pg.421]    [Pg.1512]    [Pg.421]    [Pg.335]    [Pg.55]    [Pg.319]    [Pg.80]    [Pg.192]    [Pg.181]    [Pg.222]    [Pg.22]    [Pg.23]    [Pg.80]    [Pg.106]    [Pg.27]    [Pg.169]    [Pg.221]    [Pg.312]    [Pg.318]    [Pg.157]    [Pg.24]    [Pg.26]    [Pg.51]    [Pg.5]    [Pg.588]    [Pg.1015]    [Pg.116]    [Pg.123]    [Pg.136]    [Pg.138]    [Pg.1135]    [Pg.219]    [Pg.26]    [Pg.255]    [Pg.105]    [Pg.308]    [Pg.180]   


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