Active story

Epinephrine itself does find some use in clinical medicine. The drug is used in order to increase blood pressure in cases of circulatory collapse, and to relax the bronchial muscle in acute asthma and in anaphylactic reactions. These activities follow directly from the agent s physiologic role. The biogenetic precursor of epinephrine, norepinephrine, has activity in its own right as a mediator of sympathetic nerve action. (An apocryphal story has it that the term nor is derived from a label seen on a bottle of a key primary amine in a laboratory in Germany N ohne... 

Morel et al. (1993) have reported that three flavanoids (catechin, quercetin and diosmetin) are cytoprotective on iron-loaded hepatocyte cultures. Their cytoprotective activity (catechin > quercetin > diosmetin) correlated with their iron-chelating ability (Morel et al., 1993). These compounds should also be good phenolic antioxidants so iron chelation may only be part of the story. 

Among the candidates considered for development in this series was the t-Bu amide which was subsequently given the name finasteride and became the active ingredient in both PROSCAR and PROPECiA (Figure 3.2). Section 3.1 will tell the story of the development of a manufacturing process for finasteride. As in most programs at Merck, dmg candidates showing potential for improved performance over the lead compound were approved for development as the lead... 

Shortly afterward, a scandal erupted in Basel s small chemistry community when Switzerland s Nobel laureate complained publicly that the Geigy Corporation had not paid him the proper royalties on his patented inventions. When Muller hired a politically active lawyer to represent him, the story hit the Swiss newspapers. In the end, Muller became a vice director of Geigy and received a share in the profits. 

These continuation trials tell a very different story from that told by relapse-prevention trials. They show that there is little difference between antidepressant and placebo even when the clinical trial is extended over a longer period of time. Across the eight continuation trials that have been published, 79 per cent of patients on placebo and 93 per cent of patients on active medication remained well throughout the treatment period. In these long-term studies, placebo treatment was 95 per cent as effective as drug treatment. The authors of a meta-analysis of these trials concluded that the widely held - and probably erroneous - belief that the placebo response in depression is short-lived appears to be based largely on intuition and perhaps wishful thinking .17... 

Nasmjth The lack of necessity for this cyclin D/Cdk4 activation of cyclin E is striking. What is the latest in mammalian cells They have knocked out a number of cyclin Ds it is a sort of similar story, isn t it Let s take the growth bit away. It is awfully similar to, say, Cln3 in yeast where it is important but not essential if you take it away the system still works. Is it not similar in a mammalian cell ... 

Mailer There are some stories coming out that Weel comes up in meiosis II. There might be low HI kinase activity, but there is still cyclin B present in a tyrosine-phosphorylated Cdc2 complex, and this might or might not be able to signal something about cell cycle phase. 

The story is even more complicated than we have suggested, because carbon can relax by more than one mechanism. Protons rely on dipole-dipole relaxation, which also works well for protonated carbons but badly for non-proton-ated carbons. But carbon also for example makes use of spin-rotation relaxation, which is particularly active for methyl groups. And the magnetic field dependence of the various mechanisms also differs. We realize that relaxation is a very difficult subject, and if you want to know more then there are plenty of textbooks available ... 

Steven Rose Well I think there are a lot of problems with that claim. There was a huge statistical error made in the original presentation of that, which I think has since been widely recognised. I take it that the likely story is that this chromosomal abnormality tends to produce a lower intelligence. And people with lower intelligence tend to do less well and be more likely to end up in criminal activities. 

The area of actual erg and dune formation is delimited by the 150 mm/yr isohyet. This precipitation boundary appears to have shifted strongly in the recent past. Between 20,000 and 13,000 yr BP, the southern limit of active dune formation in the Sahara desert was 800 km south of its present position and most of the now sparely vegetated Sahelian zone was an area of active dune formation at that time. These dunes, mostly of the longitudinal type, are now fixed by vegetation, but their aeolian parentage is still obvious from their well-sorted material. A similar story can be told for the Kalahari sands. Overgrazing in recent times has reactivated aeolian transport in many regions with sands. 

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