Activation thermal cell death

The release of cytochrome c from mitochondria to the cytosol is thought to be a key event for signal transduction in the apoptotic process. It has been suggested that it induces a series of biochemical reactions that result in caspase activation and subsequent cell death. Tamaki et al. [12] have developed a microchip-based system for direct monitoring of cytochrome c distribution during the apoptosis process. This system incorporated microscale cell culture, chemical stimulation, and a scanning-thermal-... 

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