Actin, peptide drug

Control of feeding behavior involves peripheral peptides (insulin, ghrelin, leptin) plus several peptides in the CNS (orexins/hypocretins, CCK, galanin, MSH, neuropeptide Y, CRH, cocaine-and-amphetamine-regulated transcript (CART)) [35, 36]. Some of the same peptides are involved in reward systems crucial to drug addiction. Specific receptor blockers are being tested for many of these peptide-receptor systems, with the hope of very selective actins with minimal side effects [35], For example, there are two CCK receptor subtypes, CCK-A and... 

The kinetics of denaturation of peptide and protein drugs have not been extensively treated. Some studies on the temperature dependence of denaturation rates have been reported. A kinetic study of the denaturation of G actin in solution using DSC yielded linear Arrhenius plots, from which values for the activation energy and the frequency factor of 23 1 kJ/mol (55.2 kcal/mol) and 76.8 sA respectively, were obtained (Fig. 215).889 Linear... 

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