Acrylic acid , reaction with carbon-centered

Based on extensive studies of C-H transformation with Pd(ii), Yu et al. recently achieved asymmetric desymmetrization in a CDC reaction (Scheme 7.26). ° Boc-L-Isoleucine (Boc-Ile-OH) was an effective chiral ligand for the Pd(ii)-catalyzed enantioselective C-H activation of a,a-diphenylacetic acid Na salt. The resultant Pd-aryl intermediate is considered to undergo insertion into styrenes or acrylates, followed by p-hydrogen elimination to afford the coupling product with a chiral quaternary carbon center in good... 

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