Acromegaly facial features

Phenytoin can cause acromegaly-like facial features, possibly related to its osteogenic actions (SEDA-20, 65). 

Phenytoin can cause vestibulocerebellar, oculomotor, and cognitive dysfunction. It can also cause gingival hyperplasia, hirsutism, and acromegaly-hke facial features. Movement disorders, symptoms of peripheral neuropathy, and endocrine changes are uncommon. Interstitial nephritis, interstitial pneumonia, and hepatotoxicity are rare. High intravenous doses are cardiotoxic. 

Sam Atotrope s coarse facial features and bulky hands are typical of patients with acromegaly. 

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