Acinar enlargement

Acinar enlargement Alveolar capillary destruction Increased lung compliance Small airways disease Inflammation Fibrosis... 

Hepatic 40 F (hepatocyte enlargement, focal sinusoidal dilation, pericentral acinar necrosis, nuclear vacuolation, portal inflammation) ... 

Histology The parenchyma is formed from pluricellular trabeculae and two (or three) layers of hepatocytes, the width of which varies from location to location. The hepatocytes are rich in glycogen, often pleomorphic and enlarged, and usually show fine-drop)-let fatty deposits. No evidence of acinar architecture or Kupffer cells is found only very few preexisting and incorporated portal fields, central veins or bile ducts are detectable. There are numerous arteries and ectatic sinusoids the latter contain no Kupffer... 

Characteristics are small acinar architecture, single-layer lining, straight luminal borders, amphophilic cytoplasm, nuclear enlargement and atypia, presence of prominent nucleoli, wispy or blue mucin content, dense eosinophilic secretions or "cancer" crystalloids, and presence of mucinous fibroplasia. 

The acinar lining projects papillary proliferations into the enlarged acinar lumina the colloid has almost completely disappeared... 

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