Acidic drugs binding affinity data

It has been observed that acidic drugs exhibit strong binding affinities for the serum albumins. Strong CD is induced in sulfaethidole when this compound binds to either crystalline or fraction V bovine serum albumin [68]. The data... 

Endothelium-dependent pulmonary artery contractions in response to arachidonic acid or methacholine appeared to be mediated by TXAj in rabbits (179). However, approximately 25% of normal New Zealand White rabbits ftuled to demonstrate pulmonary artery contraction in response to arachidonic acid, U46619 or I-BOP. These "unresponsive" rabbits were found to have only 23% of the TP receptors present on pulmonary and aortic crade membranes of "responsive" rabbits (179). Of interest was the feet that platelets fix>m "unresponsive" rabbits aggregated as well or better than platelets firom "responsive" animals vdien stirred with U46619, and no deficiency ofTP receptors nor binding affinity was found. These data sug sted that TP receptor expression may be tissue tecific. This conclusion was supported by the observation that ir bition of testosterone 5a-reductase in tats decreased TP receptor density on aortic membranes but not on platelets (180) (See V. ALTERED TP RECEPTOR FUNCTION, 3. DRUG EFFECTS, a. HORMONES below). 

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