Acid-base equilibria yielding neutral solutions

Etingov ED and Kholodova GV, Kul bakh VO and Kamatushkina AI, Acid-base properties of amphotericin B, Antibiotiki, 17, 301-305 (1972). "Titration of 66% aqueous dimethylformamide solutions of Amphotericin B with methanolic HCl and KOH yields pK s near 5.7 and 10.0. Comparison with N-acetyl-Amphotericin B (pK=6.5) and Amphotericin B-methyl ester (pK=8.8) assigns the two pK s to carboxyl and amino groups respectively. Amphotericin B is found to be almost completely zwitterionic in this solution (tautomeric equilibrium constant Kt = 1000 with respect to the neutral molecule)." S R... 

Reaction (II) could be the neutralization of acetic acid by potassium hydroxide, yielding potassium acetate which can be isolated in the crystalline state. On dissolution in water the K+ cation is only hydrated in solution but does not participate in a protolytic reaction. In this way, the weak base CH3COO is quantitatively introduced into solution in the absence of an equilibrium amount of the conjugate weak acid CH3COOH. Thus... 

Firstly, ion exchange resins when hydrated generally dissociate to yield equivalent amounts of oppositely charged ions. Secondly, as with conventional aqueous acid or alkali solutions, resins in their acid or base forms may be neutralized to give the appropriate salt form. Finally, the degree of dissociation can be expressed in the form of an apparent equilibrium constant (or pK value) which defines the electrolyte strength of the exchanger and is usually derived from a theoretical treatment of pH titration curves. ... 

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