Acid activated antimicrobials AAA

This clearly indicates that the antimicrobial activity of the stomach acid is effected by a range of dietary compounds and may be regulated by both salivary (N03, thiothyanate, iodide) and stomach (e.g. ascorbic acid) secretions. 

It is thought that bicarbonate excretions by oral tissues and the neutral pH of the saliva maintain a neutral pH in the areas inhabited by nitrite-producing bacteria, thus preventing nitrite becoming toxic to the resident bacterial flora in the oral cavity. As with denitrifying bacteria isolated from other environments 

The use of 16S rRNA technology combined with the polymerase chain 

The use of AAAs as feed supplements appears an attractive approach either in itself or in combination with pro-, pre- and synbiotics, but the lack of animal feeding studies in which the efficacy of this approach could be determined makes it difficult to assess to what extent a two-barrier (targeting control at both the stomach and intestinal level) approach is commercially feasible. Also, since the viability of probiotics may also be affected by the use of AAA to increase the disinfection activity of the stomach, probiotics may need to be formulated in a way that protects them during stomach transfer. However, its potential should be determined in future research. 

Aattouri N., Bouras M., Tome D., Marcos A. and Lemonnier D. (2001). Oral ingestion of lactic acid bacteria by rats increases lymphocyte proliferation and interferon -production . Br JNutr, 87, 367-373. 

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