Acetylcholinesterase inhibition muscarinic effects

Exposure to disulfoton can result in inhibition of acetylcholinesterase activity, with consequent accumulation of acetylcholine at nerve synapses and ganglia leading to central nervous system, nicotinic, and muscarinic effects (see Section 2.2.1.4 for more extensive discussion). 

Balduini W, Cimino M, Reno F, Marini P, Princivalle A, Cattabeni F. Effects of postnatal or adult chronic acetylcholinesterase inhibition on muscarinic receptors, phosphoinositide turnover and ml mRNA expression. Eur J Pharm 1993 248 281-288. 

TABLE 10—11. Effects of Acetylcholinesterase Inhibition at Muscarinic, Nicotinic, and CNS Receptors... 

It is known that human exposure to organophosphorus compounds can result in a variety of acute toxic effects. These arise primarily as a result of the inhibition of acetylcholinesterase. Signs of acute toxicity are due to effects on the central nervous system (anxiety, ataxia, hypotension), to muscarinic effects (wheezing, cough, rhinitis) and to nicotinic effects (muscle weakness, mydriasis and tachycardia). Other acute effects include chest tightness, abdominal cramps, confusion and convulsions. With some organophosphorus compounds, a specific syndrome may develop. This is delayed peripheral neuropathy or OP-induced delayed neuropathy (OPIDN). (For a more detailed discussion on the toxicity of organophosphorus compounds see Chapter 10.)... 

Carbachol stimulates the same muscarinic receptor as pilocarpine and also inhibits acetylcholinesterase, the enzyme that metabolizes acetylcholine. Carbachol is more potent than pilocarpine, but it causes more accommodation spasm and brow ache and may also cause anterior uveitis. Carbachol is rarely used today because of the side-effect profile. 

Diazinon, an anticholinesterase organophosphate, inhibits acetylcholinesterase in the central and peripheral nervous system. Inhibition of acetylcholinesterase results in accumulation of acetylcholine at muscarinic and nicotinic receptors leading to peripheral and central nervous system effects. These effects... 

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