Acetylcholine nictotinic receptors

Acetylcholine receptors. There are numerous receptors for ACh (Fig. 12—10), of which the major subtypes are nicotinic and muscarinic subtypes of cholinergic receptors. Classically, muscarinic receptors are simulated by the mushroom alkaloid muscarine and nicotinic receptors by the tobacco alkaloid nicotine. Nictotinic receptors are all ligand-gated, rapid-onset, and excitatory ion channels, which are blocked by curare. Muscarinic receptors, by contrast, are G protein—linked, can be excitatory or inhib-... 

Devillers-Thiery, A., Galzi, J.L., Eisele, J.L., Bertrand, S., Bertrand, D. and Changeaux, J.P. (1993) Functional architecture of the nictotinic acetylcholine receptor a prototype of ligand-gated ion channels. Journal of Membrane Biology 136, 97-112. 

Martin, R.J., Robertson, A.P., Bjorn, H. and Sangster, N.C. (1997) Heterogeneous levamisole receptors a single-channels study of nictotinic acetylcholine receptors from Oesophagostomum dentatum. European Journal of Pharmacology 322, 249-257. 

McGehee, D.S. and Role, L.W. (1995) Physiological diversity of nictotinic acetylcholine receptors expressed by vertebrate neurons. Annual Review of Physiology 57, 521-546. 

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