Acetyl phenylenediamine

If the diazonium groups result from the diazotation of poly-/>-amino-styrene, the macroradicals will initiate grafting. Contrarily, if >-(N-acetyl) phenylenediamine is diazotized and used as initiator of a first monomer, a polymer is obtained with an acetamino. phenyl end group (-CGH4-NH-Ac). After hydrolysis of this last and diazotation of the free amine group, the polymeric terminal diazonium salt can be used with ferrous ions for the synthesis of block copolymers. 

The structure of this compound is confirmed by the preparation of the 1-acetyl derivative, acid degradation to 4-methylquinoxalin-3-one-2-carboxylic acid (12), and alternative synthesis from the acid chloride of (12) and AW -dimethyluread A most unusual cyclization occurs when AW-dimethyl-o-phenylenediamine (15) is treated with alloxan in ethanolic solution this apparently involves an A-methyl group and leads to the formation of the spirobarbituric acid (16). The struc-... 

The tropolone alkaloid of Liliaceae species, colchicine, is transformed by acetylation, alkaline cyclization, and dehydration into the tetracyclic pyrrolotropone acetyl anhydrocolchicine [77TL2977 83AX(C)1709]. When the dicarboxylic acid anhydride groups of puberulonic and stipitatonic acids (metabolites of Penicillium species) condense with o-phenylenediamine, another tetracyclic pyrrolotropone structure is formed (51JCS1139 59JCS2847). 

We (K1) attempted to develop a noncompetitive assay based on the anti-idiotype antibodies for a conjugated bile acid metabolite, ursodeoxycholic acid 7-A-acetyl-glucosaminide (UDCA 7-NAG), which is expected to serve as a diagnostic index for an autoimmune disease, primary biliary cirrhosis. In our assay, the hapten UDCA 7-NAG, a /3-type antibody, and a biotin-labeled a-type antibody were simultaneously added to a microtiter plate coated with an F(ab )2 fragment of a specific anti-UDCA 7-NAG antibody, then incubated at room temperature for 8 h. Bound biotin was then detected with HRP-labeled streptavidin, whose enzyme activity was measured using o-phenylenediamine/H202 as a substrate. This noncompetitive assay system provided a subfemtomole-order sensitivity (detection limit 118 amol) that was 7 times lower than the competitive immunoassay using the same anti-hapten antibody (K2), even with a common colorimetric detection (Fig. 13). Somewhat improved specificity was also obtained namely, better... 

Benzothiadiazepines, e.g. (546), can be prepared by reacting o-phenylenediamine with appropriate sources of the S—C—C fragment, e.g. chlorosulfonyl acetyl chlorides... 

Another interesting reaction of diamines with isothiocyanates is the formation of l,3,5-triazepine-2-thione derivatives by the action of various classes of diamines on 2,3,4,5,6-penta-O-acetyl-D-gluconyl isothiocyanate (32). The reaction has been performed in acetonitrile or N,N-dimethyl-formamide solution with o-phenylenediamine, diaminomalononitrile, 5,6-diamino-l,3-dimethyluracil, 4,5-diamino-2,6-dithiopyrimidine, 4,5-diamino-2-thiopyrimidine, and 4,5-diaminopyrimidine, and afforded... 

Acetylated derivatives of Baylis-Hillman adducts derived from ethyl acrylate and aromatic and heteroaromatic aldehydes are synthetically accessible three-carbon fragments that readily react with phenylenediamine under the influence of base to provide l,4-benzodiazepin-2-ones in good overall yield, as depicted in Scheme 71 <2006S4205>. 

In acetonitrile some 1,5-benzodiazepine derivatives, prepared by condensation of o-phenylenediamine with 4,6-dimethylbicyclo[3.3.1]nona-3,6-diene-2,8-dione, have been reductively acetylated to substituted barbaralanes [344]. 

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