Acetyl galactosamine

The ABO blood group substances in the red cell membrane are complex glycosphingohpids the immunodominant sugar of A substance is A -acetyl-galactosamine, whereas that of the B substance is galactose. 

Selective Oxidation of Terminal B-D-Galactose (or N-acetyl-galactosamine) Groups... 

Figure 2.10 Structure of two sample oligosaccharide side chains (one N-linked the other O-linked) found in glycoproteins. Man manose Gal galactose SA sailic acid GlcNAc W-acetyl glucosamine GalNAc W-acetyl galactosamine...

Morquio A MPS IVA AT-acetyl-galactosamine 6-sulfatase Keratan sulfate... 

Maroteaux-Lamy MPS VI AT-acetyl-galactosamine-4-sulfatase Dermatan sulfate... 

Chondroitin sulfates (CS) are ubiquitous components of extracellular matrices of all connective tissues such as the artery and tendon and exhibit a variety of biological functions. They are linear copolymers made up of dimeric units composed of glucuronic acid and N-acetyl galactosamine. The first biological investigation... 

Figure 12.15 Gangliosides. The prefix mono-, di, tri- or tetra- denotes the number of sialic acid W-acetyl neuraminic acid, NANA) residues present in the molecule. The many different gangliosides have complex structures and for convenience shorthand notations are used. The two commonest were introduced by Svennerholm, who named the parent compound GM1, and Wiegnandt, who named it Ggnti. The latter system gives enough information for the structures to be worked out from the shorthand form once the symbols have been learnt. GalNAc represents N-acetyl galactosamine in the above structure.

As described earlier in Section IV.A., several of the carbohydrate sequences that serve as receptors for enteric pathogens have been identified. For EPEC, these receptors are located on the surface of host epithelial cells and are often comprised of galactose, N-acetyl-galactosamine, lactosyl... 

OR streptavidin, followed by biotin-N-acetyl-galactosamine clearing and biotin-DOTA °Y ... 

This enzyme [EC 2.8.2.5] catalyzes the reaction of chon-droitin with 3 -phosphoadenylylsulfate to produce adenosine 3, 5 -bisphosphate and chondroitin 4 -suffate. Specifically, the sulfation is at the 4-position of A-acetyl-galactosamine residues of chondroitin. This enzyme is distinct from that of chondroitin 6-sulfotransferase [EC 2.8.2.17]. 

A-acetyl galactosamine (1 — 4) glucuronic/id-uronic acid (1—with 1 sulfo group... 

Fraction Galactose N-acetyl- galactosamine. V-acetyl- neuraminic acid Phosphate... 

The genetic basis for the ABO blood groups is well understood. There are three alleles, variants of a gene, that encodes a glycosyltransferase. In A type individuals, this enzyme transfers N-acetyl-galactosamine from a carrier molecule, called UDP... 

Analysis by H-NMR techniques and different calculation methods by Bush et al. [118] showed that the minimum energy conformation obtained by the Hopfinger potential as well as the HSEA potential described the experimental data for the terminal A-blood group tetrasaccharide very well, whereas the modified Scheraga potential did not reproduce the experimental data — NOE and longitudinal relaxation times — adequately. The glycosidic bond of fucose showed calculated and experimental values of cp = 60° and i — 10° and that of iV-acetyl-galactosamine showed cp = —70° and J/ = -40°. 

Fig. 14. Salvage pathways of nucleotide sugars. L-fucose (11), (3-L-fucose-l-phosphate (12), GDP-p-L-fucose (13), A fucokinase (EC 2.7.1.52), B GDP-Fuc pyrophosphorylase (EC 2.7.7.30). D-galactose (14), a-D-galactose-l-phosphate (15), UDP-a-D-galactose (16), C galactokinase (EC 2.7.1.6), D UDP-Gal pyrophosphorylase. IV-acetyl-D-galactosamine (17), Al-acetyl-a-D-galactosamine-l-phosphate (18), UDP-lV-acetyl-a-D-galactosamine (19), E IV-acetyl-galactosamine kinase (EC 2.7.1. ), F UDP-GalNAc pyrophosphorylase (EC 2.7.7. )...

Fig. 10.4 Structures of the Lewis and blood group antigens expressed in H. pylori strains. See Moran (2008) for details. Abbreviations Fuc, fucose Gal, galactose GalNAc, IV-acetyl-galactosamine GlcNAc, A-acetyl-glucosamine Neu5Ac, A-acetyl-neuraminic (sialic) acid...

---