4- Acetyl-2-ethyl-5-phenyl

Acetyl-ethyl-phenyl- E2, 23 (2-Aeylamino-ethoxy)-hydroxy- El, 317 (l-Aeyloxy-vinyl)-diorgano- El, 253 A lk oxy-dialkylamino-... 

Finally, the pyrrolo[2,l-/ [l,2,4]triazine moiety was also encountered in azulene derivatives. Reactions of l,8-diamino-3-phenyl-l-azaazulenium salt 54 with triethyl orthoformate and acetic anhydride gave l-phenyl-2a,3,5-mjzjbenzb. //]jzulcncs 55 and 56. The reaction of the same salt with ethyl pymvate gave 4-acetyl-l-phenyl-2a,3,5-triazabenz[c, /]azulene 14 <2000H(53)323>. 

The presence of small amounts of water was found to be essential even for hydrophobic ionic liquids (284). When a-chymotrypsin (in the form of salt-free lyophilized powder) was applied for the transesterification of Ai-acetyl-L-phenyl-alanine ethyl ester with 1-propanol in the dry ionic liquids [BMIM]PFg and [OMIMJPFg, little enzymatic activity was observed. The maximum activity was observed when 0.5 vol% water was added to the ionic liquids. Supercritical CO2 was also sufficient to activate the enzyme in dry ionic liquids. The addition of water to the supercritical C02-ionic liquid system further enhanced the enzymatic activity. 

Acetyl-2-phenyl- (eq. 12.60) and 3-ethyl-2-phenylindolizines were hydrogenated to the corresponding 5,6,7,8-tetrahydro derivatives over Raney Ni at room temperature.113 Water and Margolis hydrogenated various 1-substituted 2-phenylindolizines, which were not hydrogenated with palladium or platinum catalysts, over Raney Ni to the 5,6,7,8-tetrahydro derivatives in ethanol at room temperature and 0.41 MPa H2.115... 

Peroxid (2-Brom-l,l-dimethyl-ethyl)-(phenyl-acetyl)- E13/1, 807 (Cl -> O —OR)... 

Heroine.—Two derivatives of morphine, used as synthetic narcotics or hypnotics, deserve attention. The first of these is known as heroine. It is the di-acetyl morphine. It resembles morphine in its action but does not produce as great mental depression. The second synthetic drug is the ethyl phenyl ether corresponding to codeine. It is known as dionine. It resembles codeine in its action. The benzyl phenyl ether is known as peronine. 

Doepp and his co-workers have reported the synthesis and photochemical activity of some novel 3,5-diacetyl-1,4-dihydropyridines. The principle reaction is aromatization. Crystals of ethyl l-acetyl-4-phenyl-l,4-dihydro-3-pyri-dinecarboxylate contain centrosymmetric pairs of molecules. The irradiation of these brings about dimerization to yield the anti-dimer (101). Irradiation in solution alfords mixtures of the dimer (101) and the cage compound (102). ... 

Methyl-4-(2-phenyl-ethyl)-lH-pyrazol [Schmp. 55-57° (Lcichtbenzin)] wird aus 2-Acetyl-4-phenyl-butanal und Hydrazin-Hydrat (Methanol 10 min. RiickfluB) zu 82% erhalten1296. 

Aeetyl-3,5-dimethyl-1 -(4-nitro-phcnyl)- 515 4-Acetyl-3,5-dimethyl-l-phenyl- 625 4-Acetyl-l, 3-diphenyl- 533, 536 3(5)-Acetyl-5(3)-ethoxycarbonyl-4-methy 1- 510 4-Acetyl-l-ethoxycarbonyl-3-methyl- 483 4-Acetyl-l-cthoxycarbonyl-5-methyl- 483 3(5)-Acetyl-4-ethoxycarbonyl-5(3)-phenyl- 524 l-Acetyl-4-cthyl- 613 4-(l-Acetyl-ethyl)-3,5-dimcthyl- 526 1 -Acetyl-3-fluor- 613... 

Procedure. React the acetyl group in Warfarin [3(a-phenyl- 8-acetyl-ethyl)-4-hydroxycoumarine] with iodine in alkaline solution (as hypo-iodite) to form iodoform. Filter off the precipitated iodoform, dissolve in methanol and add one part of this solution to nine parts of a supporting electrolyte consisting of 40 ml. of acetone, 20 ml. of ethanol and 40 ml. of 0-5 N sulphuric acid. Deoxygenate and record the polarographic curve. 

Ethyl d,l-(a-Phthlalimidophenylacetyl) acetoacetate refluxed 14 hrs. in pyridine until COg-evolution ceases l-acetyl-3-phenyl-2,5(3H)-dioxo-5H-pyrrolo[2,l-a]-isoindole. Y 80-83%. F. e. s. K. Adank et al., Helv. 44, 2131 (1961). 

Acetyl-5-chloro-3-phenyl Ethyl 2-benzyl-3-oxobutanoate Cone. H Cl 50-90 [7]... 

C NMR, 7, 498 (79TH51600) 2H-Azepine-4-carboxylic acid, 7-(4-bromophenyl)-3-methoxy-2-oxo-6-phenyl-X-ray, 7, 494 <79H(12)1423> 3H-A2epine-4-carboxylic acid, 6-acetyl-2-ethoxy-3-oxo-7-phenyl-, ethyl ester H NMR, 7, 503 <81H(16)363) 3H-Azepine-4-carboxylic acid, 2,6-diethoxy-3-oxo-7-phenyl-, ethyl ester H NMR, 7, 503 <81H(16)363) 3H-Azepine-4-carboxylic acid, 2-ethoxy-3-oxo-6,7-diphenyl-, ethyl ester HNMR, 7, 503 <81H(16)363) 3H-Azepine-4-carboxylic acid, 2-ethoxy-3-oxo-7-phenyl-, ethyl ester... 

Analogously to ynamines and o, /3-acetylenic ketones, 4-aminobut-3-yn-2-ones react with 1,3-dipoles (68HCA443 73HCA2427 92KGS867). The reaction of 4-dimethylaminobut-3-yn-2-one with diphenylketene follows a route of [2-1-21-cycloaddition (30°C, THF, 1 h) to give 2-acetyl-3-dimethylamino-4,4-diphenyl-cyclobut-2-en-l-one (377) in 15% yield. With ethyl azidoformate (30°C, THF, 3 h), the tiiazole 378 is formed in 82% yield, whereas with phenyl isocyanate, the quinoline 379 is the product (by a [2- -4] scheme) in 70% yield (68HCA443). 

A sulfoxide was obtained by oxidation of 8-[(4-trifluoromethylmercapto-phenyl)methoxy] derivative 358 with 36% H2O2 in AcOH (98MIP7) and by oxidation of l-[2-(4-thiomorfolin-l-yl)acetyl]-7-(3-methoxyphenyl)-A-methyl-A- [3,5-bis(trifluoromethyl)phenyl]ethyl -5-oxo-1,2,3,5-tetrahydro-pyrido[l,2,3-i/ ]quinoxaline-6-carboxamide with 3-chloroperbenzoic acid (01MIP12). A 7-[(4-fluorophenylsulfonyl)methyl] derivative was obtained by oxidation of a 7-[(4-fluorophenylsulfanyl)methyl]perhydropyrido[l,2-u] prazine with 3-chloroperbenzoic acid in CHCI3 (01EUP1074257). 

Polyphosphoric acid in cyclization of ethyl a-acetyl-/3-(2,3-dimethoxy-phenyl)propionate to 6,7-dimeth-oxy-3-methylindene-2-carboxyl-ate, 40, 43... 

The following abbreviations are commonly used for substituent groups in structural formulae Ac (acetyl), Bn or PhCH2 (benzyl), Bz or PhCO (benzoyl), Et (ethyl), Me (methyl), Me3Si (not TMS) (trimethylsilyl), Bu Me2Si (not TBDMS) (rerf-butyldimethylsilyl), Ph (phenyl), Tf (triflyl = trifluoromethanesulfonyl), Ts (tosyl = toluene-p-sulfonyl), Tr (trityl). 

The intramolecular formal [3+3] cycloaddition reaction of l- [l-phenyl-2-(4-oxobut-2-enyloxy)ethyl]amino cyclo-hexen-3-one at 150°C in the presence of piperidinium acetate afforded /ra 3--l,4a-77-l-phenyl-l,2,4,4a,7,8,9,10-octahydro[l,4]oxazino[4,3- ]quinolin-7-one <2002JA10435>. At 85°C, the 6-(l-piperidnyl)-l,2,4,4a,5,6,7,8,9,10-dec-ahydro derivative formed, which could be converted into the l,2,4,4a,7,8,9,10-octahydro derivative by heating at 150 °C. Cyclization of iV-[(2-butyl-2-oxoethoxy)acetyl]-3,4-dimethoxyphenylethylamine on the action of TFA gave llb-butyl-1,3,4,6,7,1 lb-hexahydro[l,4]oxazino[3,4- ]isoquinolin-4-one <1997JOC2080>. 

Ethyl a-ACETYL-/3-(2,3-DiMETHOXY-phenyl)propionate, 31, 56 Ethyl a-acetyl-/3-(3,4-dimethoxyphenyl)-propionate, 31, 58... 

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