Acetanilide, 2,2,2-trifluoro

The checkers suspected that some product was lost during the drying process. Therefore, they purified the crude product by sublimation at 55° (0.15 mm.), which gave 3.76-3.84 g. (80-81%) of jV-trifluoro-acetanilide in half-scale runs (Note 6). 

Abietylamine, dehydro-, A tnfluoro- [Acetamide, 2,2,2-trifluoro-/V-[ [1,2,3,4,4a, 9,10,1 Oa-octahydro-l, 4a-dtmethyl-7-(l-methylethyl)-l -phenanthrenyl ] -methyl]-, [17 (la,4ad,10aa))-, 125 Acetamides, A-arylalkyl-, 7 Acetanilide, 2,2,2-tnfluoro- [Acetamide, 2,2,2-tnfluoroTV-phenyl-], 122 Acetic acid, cyano-, methyl ester, 63 Acetic acid, methoxy-, 70 Acetic acid, phenoxy-, 68 Acetic acid, phenyl- [Benzeneacetic acid],... 

Similar evidence for the alkaline hydrolysis of 2,2,2-trifluoro-N-methyl-acetanilide(I) and other similar amides was obtained by Beichler and Taft27, who showed that the rate of hydrolysis is given by the expression... 

The Skraup reaction is a good illustration of this common approach, as illustrated by the series of syntheses of 5,7-difluoro- and 5,6,7-trifluoroquinolines 2a,b proceeding in high yields on the basis of 3,5-difluoro- and 3,4,5-trifluoro-anilines la,b (Scheme 3) [5]. In a similar way 5,6,8-trifluoroquinolines 4a,b have been obtained from 2,4,5-trifluoro substituted acetanilide 3 and acrolein or crotonic aldehyde [6-8]. 5,7,8-Trifluoroquinoline has also been obtained from 2,3,5-trifluoro-acetanilide, while 6-trifluoromethyl-5,7,8-trifluoroqumoline - from 2,3,5-trifluoro-4-trifluoromethyl acetanilide, respectively [6]. The Skraup cyclization is also an effective synthetic took to transform 2,3,4,5-tetrafluoro substituted aniline 5 into... 

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