Cetirizine Acenocoumarol

Cetirizine is a non-sedating metabolite of hydroxyzine (SEDA-18, 181) (SEDA-19, 172) (SEDA-21, 172) (SEDA-22, 178). There is only minor hepatic metabolism of cetirizine (1), which is excreted unchanged in the urine. It has not been associated with dysrhythmias. Skin reactions have been reported, and the anticoagulant activity of acenocoumarol may be potentiated (SEDA-22, 178). 

Berod T, Mathiot I. Probable interaction between cetirizine and acenocoumarol. Ann Pharmacother 1997 31(1) 122. 

Extracted acebutolol, acenocoumarol, acepromazine, aceprometazine, acetaminophen, ajmaline, albuterol, alimemazine, alminoprofen, alpidem, alprazolam, alprenolol, amisul-pride, amitriptyline, amodiaquine, amoxapine, aspirin, atenolol, benazepril, benperidol, benzocaine, benzoylecgonine, bepridil, betaxolol, bromazepam, brompheniramine, bumad-izone, bupivacaine, buprenorphine, buspirone, caffeine, carbamazepine, carbinoxamine, carpipramine, carteolol, celiprolol, cetirizine, chlorambucil, chlordiazepoxide, chlormeza-none, chlorophenacinone, chloroquine, chlorpheniramine, chlorpromazine, chlorpropamide, cibenzoline, cicletanine, clemastine, clobazam, clomipramine, clonazepam, clonidine, clorazepate, clozapine, cocaine, codeine, colchicine, (yamemazine, cyclizine, cycloguanil, cyproheptadine, c arabine, dacarbazine, daunorubicin, debrisoquine, demexiptiline, de-sipramine, dextromethorphan, dextromoramide, dextropropo3gq)hene, diazoxide, diclofenac, dihydralazine, diphenhydramine, dipyridamole, disopyramide, dosulepine, doxepin. 

Findings from a retrospective review suggest that the anticoagulant effects of acenocoumarol may be reduced by loratadine, ebas-tine, or cetirizine. Conversely, an isolated report describes bleeding and a markedly raised BSR in an elderly man taking acenocoumarol and cetirizine. 

A retrospective review of patients taking acenocoumarol with loratadine, ebastine, or cetirizine found that DSTRs were decreased during concurrent use, but no thromboembolic event was noted. The authors consider that temporary increases in the anticoagulant dosage might be required. ... 

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