Aspirin Acenocoumarol

Clinically important, potentially hazardous interactions with acenocoumarol, aspirin, bivalirudin, butabarbital, capsicum, ceftobiprole, dabigatran, danaparoid, desvenlafaxine, dong quai, ginger, horse chestnut (bark, flower, leaf, seed), palifermin, red clover, salicylates, tazobactum, tirofiban... 

In a pharmacological study in patients stabilised on acenocoumarol, aspirin 2.4 g daily for one week inereased faeeal blood loss from an average of 1.1 mL to 4.7 mL. While taking aspirin, 11 of 17 patients required a 29% reduction in their acenocoumarol dose from a mean of 3.1 mg to 2.2 mg. One patient required a slight inerease of 0.5 mg, and the remaining 5 required a dose reduction of less than 0.5 mg. ... 

Enalapril, paracetamol, sotalol, dipyrone, vancomycin, captopril, fluconazole, cefazolin, metoprolol, aspirin, ticlopidine, prednisolone, propranolol, digoxin, sildenafil, furosemide, dexamethasone, carvedilol, ketoprofen, nifedipine, terbinafine, acenocoumarol, spironolactone/urine HPLC DAD Column LiChroCART Purospher STAR, RP-18e (250 x 4 mm, 5 pm) Mobile phase MeOH ACN 0.05 % TFA in water (gradient elution) Detection DAD X = 200 50 nm Adjusted to pH 7.0, protein precipitation LOD 0.01-1.44 pg/mL LOQ 0.04-4.35 pg/mL [72]... 

Extracted acebutolol, acenocoumarol, acepromazine, aceprometazine, acetaminophen, ajmaline, albuterol, alimemazine, alminoprofen, alpidem, alprazolam, alprenolol, amisul-pride, amitriptyline, amodiaquine, amoxapine, aspirin, atenolol, benazepril, benperidol, benzocaine, benzoylecgonine, bepridil, betaxolol, bromazepam, brompheniramine, bumad-izone, bupivacaine, buprenorphine, buspirone, caffeine, carbamazepine, carbinoxamine, carpipramine, carteolol, celiprolol, cetirizine, chlorambucil, chlordiazepoxide, chlormeza-none, chlorophenacinone, chloroquine, chlorpheniramine, chlorpromazine, chlorpropamide, cibenzoline, cicletanine, clemastine, clobazam, clomipramine, clonazepam, clonidine, clorazepate, clozapine, cocaine, codeine, colchicine, (yamemazine, cyclizine, cycloguanil, cyproheptadine, c arabine, dacarbazine, daunorubicin, debrisoquine, demexiptiline, de-sipramine, dextromethorphan, dextromoramide, dextropropo3gq)hene, diazoxide, diclofenac, dihydralazine, diphenhydramine, dipyridamole, disopyramide, dosulepine, doxepin. 

Noninterfering amiloride, acebutolol, acenocoumarol, acetaminophen, aspirin, allopuri-nol, ambroxol, amoxicillin, atenolol, bendroflumethiazide, benzbromarone, bezafibrate, biperiden, bisacodyl, bromazepam, butizide, captopril, cimetidine, ciprofloxacin, clobu-tinol, clonidine, cotinine, diazepam, diclofenac, digitoxin, digoxin, dihydrocodeine, dihy-droergotamine, diltiazem, doxepin, doxycycline, enalapril, erythromycin, fenoterol, furosemide, glibenclamide, heparin, h3qjoxanthine, ibuprofen, indomethacin, isosorbide... 

A further study found that aspirin 1 g daily combined with unnamed anticoagulants was associated with a threefold higher incidence of bleeding episodes than those taking anticoagulants alone (13.9 versus 4.7 per 100 patients per year). However, in another study there was no difference in haemorrhagic risk between patients receiving aspirin 500 mg daily and acenocoumarol or acenocoumarol alone. ... 

---