Solutions accuracy

Initiation of registration batches, NDA submission Specificity, linearity, range, accuracy, solution stability, precision, LOD, LOQ... 

To obtain higher-accuracy solutions for Problem 15.2, divide the interval into more subintervals. Increase n from 4 as in Problem 15.2 to 8, and decrease h from 1 to. You will generally obtain a tridiagonal system of n — 1 linear equations up to 7 in the present case. For large n, solving the system of equations with paper and pencil becomes impractical, and it is necessary to find algorithms suitable for computation by computers. 

In this approach, similar to the determination of intrinsic accuracy, the accuracy solutions are prepared by spiking a known quantity of authentic samples and drug... 

Accuracy. Sample solutions of known concentration (e.g., spiked placebo) are used for the accuracy determination. Experimental work may be organized so that the same stock solutions are used to prepare both linearity and accuracy solutions. The accuracy solution must be exposed to normal test conditions (e.g., mixing in a heated dissolution vessel). Determine any bias that is caused by the sampling and analysis of the solutions. If a dissolution profile of the drug product is required, accuracy determinations at different concentrations of the required profile will need to be performed (e.g., at 40, 75, and 110% of theoretical release). The results are reported as percent theory. 

The finite-size DMRG algorithm provides high-accuracy solutions even when the states of the full Hamiltonian have inhomogeneous (symmetry breaking) properties. 

Recent studies showed that the choice of the CCD as main component in the system improves the acquired frame quality and gives higher-accuracy solutions to users. Infrared... 

Once this eigenvalue obtained, the corresponding eigenvector Is then determined using the Iterative conjuguate gradient method 15-16 to solve the linear system ( fl - Go ) o> 0. A high accuracy solution ( < 10 a.u. ) Is obtained In 15 Iterations. 

Zhang J (1997) Accelerated multigrid high accuracy solution of the convection-diffusion equation with high Reynolds number. Numer Methods PDEs 13 77-92... 

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