Accepted goal setting

Simple, simple, simple. Nearly everyone is looking for fast, convenient foods that are simple to prepare. Simplicity also can encompass cost-effectiveness. I accept this set of requirements as a dietary fact of twenty-first-century life, so I hope you will find that these quick and easy smoothie recipes work for you in meeting those goals with flying colors. 

Another issue is reproducibility. The formulation may work perfectly in an in vitro test system, but the dosage form requires aerosolization, and lung deposition is a function of the characteristics of the aerosol (dose, mass concentration, droplet/particle size, etc.) and the nature of the inspiratory maneuver, a factor that the patient has control over. These factors can influence performance to a far greater extent than can be built into a particle, and thus the term controlled does not seem a defensible objective for pulmonary delivery. The vagaries of the deposition profile and of the amount that will deposit also imply that sustaining a certain drug concentration is a difficult proposition, but the loosest definition extended release, seems an acceptable goal within the boundaries set by the clearance mechanisms. 

Analytical variation adds imprecision to biological variation. Conversely, if biological variation is high, analytical variation becomes relatively less important and the requirement for analytical precision diminishes (Fraser, 1983). The goal set-up is that variance due to analytical error should not exceed 20% of the variation (Fraser, 1983). It can be shown that this is acceptable when CVj j y,i < or... 

A detailed scrutiny of goal-setting regulations would be unlikely to reveal any safety goals expressed in quantitative or measurable terms. The use of precise numerical values would have many of the drawbacks of detailed prescriptive regulations, being inflexible and prone to become out of date. It would be difficult to define target values that were universally acceptable and appropriate to all circumstances. 

It is central to the goal-setting approach to safety regulation that the employer or operator should make an assessment of risks and then take appropriate measures to ensure health and safety "so far as is reasonably practicable", in the words of HSWA. This is usually expressed as making risks As Low As Reasonably Practicable, or ALARP in the words of HSE s guidance on the tolerability of risks from nuclear installations. ALARP is associated with the concepts of intolerable and broadly acceptable risks. 

Each cycle consists of plan, execute, and evaluate phases. Set goals, level of investment, and acceptable risks plan and decide what will be evaluated and how it will affect future cycles determine fallbacks execute the plan evaluate the outcome. For software development cycles this often translates into plan, specify, design and implement, and evaluate. 

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