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Absorption, distribution, metabolism high-throughput assays

The sensitivity and selectivity brought to drug discovery by the routine use of HPLC/MS/MS has revolutionized biopharmaceutical capabilities. This impact has been realized in the form of increased throughput and decreased cycle time. In a highly significant sense, these new analytical methods have enabled the introduction of absorption distribution metabolism excretion studies much earlier in discovery than previously possible. At one time the investment of lengthy assay development for transport studies on a discovery candidate was nearly unthinkable. With HPLC/MS/MS, this barrier has been removed. Prime ADME information can be provided at the earliest stages of discovery to aid in the selection of lead candidates. [Pg.265]

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See also in sourсe #XX -- [ Pg.398 ]



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