High-throughput metabolic

HIGH THROUGHPUT METABOLIC AND PHYSICOCHEMICAL PROPERTY ANALYSIS STRATEGIES AND TACTICS FOR IMPACT ON DRUG DISCOVERY SUCCESS... 

HIGH THROUGHPUT METABOLIC AND PHYSICOCHEMICAL PROPERTY ANALYSIS... 

The LC-MS methods introduced by Ackermann et al. and Korfmacher et al. paved the way for more powerful platforms for high-throughput metabolic stability screening that featured the use of LC-MS/MS [80,92], These powerful methods relied on robotic sample preparation systems that were integrated with an automated LC-MS/MS system. 

Zhong, F. et al., High throughput metabolic stability screening by MALDI triple quadra-pole analysis, The Application Note Book, September, 24, 2007. 

Villas-Boas, S.G., Moxley, J.F., Akesson, M., Stephanopoulos, G. et al (2005) High-throughput metabolic state analysis the missing link in integrated functional genomics of yeasts. Biochem. J, 388, 669-677. 

E. Berthier, A.B. Theberge, B.P. Casavant, Guo Chunjun, C. Wang, D.J. Beebe and N.P Keller, Suspended microfluidics An open and user-friendly technology platform for high-throughput metabolic studies. Proceedings of the 2012 MicroTas Conference, Okinawa, Japan, (2012). 

Fischer, E., Zamboni, N., and Sauer, U. (2004) High-throughput metabolic flux analysis based on gas... 

Dietrich, J.A., A.E. McKee, and J.D. Keasling, High-throughput metabolic engineering Advances in small-molecule screening and selection. Annu. Rev. Biochem., 2010. 

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