Absorption, distribution, metabolism excretion pharmacokinetic

Experimental Data Pharmacokinetics - Absorption, Distribution, Metabolism, Excretion 153... [Pg.141]

Pharmacokinetic parameters Absorption Distribution Metabolism Excretion Other studies... [Pg.419]

The issues related to pharmacokinetics - drug absorption, distribution, metabolism, excretion - have always been important to the success of the drug discovery process. In many cases, not enough attention was paid to these factors in the early stages of the discovery... [Pg.27]

One of the factors that can alter the response to drugs is the concurrent administration of other drugs. There are several mechanisms by which drugs may interact, but most can be categorized as pharmacokinetic (absorption, distribution, metabolism, excretion), pharmacodynamic (additive or antagonistic effects), or combined interactions. The general principles of pharmacokinetics are discussed in Chapters 3 and 4 the general principles of pharmacodynamics in Chapter... [Pg.1382]

Many of the monographs in Part 2 contain a section with the heading Disposition in the Body . The information in these statements has been obtained from a detailed survey of published papers and other reference sources. Certain monographs have a single reference at the end of the statement and this indicates that all the disposition information has been obtained from that source. Wherever possible, information is included on absorption, distribution, metabolism, excretion, therapeutic concentration, toxicity, and pharmacokinetic parameters. [Pg.1680]

The pKa is an important physicochemical parameter. The analyte pKa values are especially important in regard to pharmacokinetics (ADME—absorption, distribution, metabolism, excretion) of xenobiotics since the pKa affects the apparent drug lipophilicity [59]. Potentiometric titrations and spectrophome-tric analysis can be used for pKa determination however, if the compound is not pure, is poorly soluble in water, and/or does not have a significant UV chromophore and is in limited quantity, its determination may prove to be challenging. [Pg.179]

Pharmacokinetics absorption, distribution, metabolism, excretion or, how the body, well or sick, affects drugs... [Pg.38]

Tillement, J.-P. and Tremblay, D. (2007) Clinical pharmacokinetic criteria for drug research the why and how of absorption, distribution, metabolism, excretion, and toxicity research, in ADME-Tox Approaches, Vol. 5 (eds B. Testa and... [Pg.6]

This edition incorporates a new trend in drug discovery namely the consideration of pharmacokinetics and ADME properties of drugs (absorption, distribution, metabolism, excretion) early in the process. As prospective new drugs are tested in more complex systems (with... [Pg.384]

FIGURE 12.9 Schematic showing major absorption, distribution, metabolism, excretion and pharmacokinetic (ADME/PK) issues encountered in the lead optimization process as well as possible sources for the issue. (Adapted from Eddershaw et al. [9]. Copyright 2000, with permission from Elsevier.)... [Pg.368]

Keywords Cannabinoids Pharmacokinetics Tetrahydrocannabinol Cannabidiol Absorption Distribution Metabolism Excretion Interpretation Oral fluid Sweat Hair Plasma Urine Alternate matrix Marijuana... [Pg.658]

Key words Absorption, distribution, metabolism, excretion, and toxicity (ADME/T), High-throughput screening (HTS), Hit-to-lead, Inhibitor design. Medicinal chemistry. Pharmacokinetics (PK), Pharmacophore, Rational design. Structure-activity relationship (SAR)... [Pg.85]

An optimization step, that deals with the improvement of the lead structure. The optimization process takes primarily into account the increase in potency, selectivity and toxicity. Its characteristics are the establishment and analysis of structure-activity relationships, in an ideal context to enable the understanding of the molecular mode of action. However, an assessment of the pharmacokinetic parameters such as absorption, distribution, metabolism, excretion and oral bioavailability is almost systematically practised at an early stage of the development in order to eliminate unsatisfactory candidates. [Pg.31]

Pharmacokinetic phase Fate of the dmg in the organism absorption, distribution, metabolism, excretion ( ADME ) Control the bioavailability, i.e. the ratio of the administered dose over the concentration at the site of action, in function of the time... [Pg.32]

Abbreviations. ADMET = absorption, distribution, metabolism, excretion, toxicology CYP = cytochrome P450 ELISA = enzyme-linked immunosorbent assay PD = pharmacodynamics PK = pharmacokinetics — = not applicable. [Pg.105]

The sequence of the pharmacokinetics written summary Brief summary Methods of analysis Absorption Distribution Metabolism Excretion... [Pg.263]

Absorption, distribution, metabolism, excretion, and toxicology (ADMET) properties determine the pharmacokinetic and safety behavior of compounds and thus to a large part, how effective a compound acts as a drug, how the compound has to be dosed, and what safety window has to be considered. Due to the decisive role of ADMET properties in lead optimization and drug development, these parameters are investigated very early by in vitro systems. For example, Caco-2 cell lines are used to estimate permeability of compounds, while liver microsomes are used to study metabolic stability of novel compounds in vitro [1,2]. [Pg.245]

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