Aberrant caspase activity

Caspases kill cells by cleaving abroad spectrum of cellular substrates. To ensure that the death pathway is not accidentally activated, caspase activity must be carefully regulated to prevent aberrant caspase activation. Some members of the inhibitor of apoptosis protein (lAP) family can suppress caspase activity thus avoiding unwanted... 

Too strong, too weak, or aberrant activation of one or more caspases is a hallmark of many human ailments. In Table 1 we provide a list of experimental diseases in... 

Recently garcinol (46), also called camboginol, has attracted considerable interest because of its associated beneficial health properties, including antiulcer activity [59], anti-glycation activity [60], cancer chemopreventive activity against colonic aberrant crypt foci (ACF) in an animal model [63], induction of apoptosis through cytochrome c release and activation of caspases in human leukemia cells [61]. It also showed strong antioxidant activity [59,60]. 

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