Abdominal pain praziquantel

Praziquantel can cause dose-related nausea, vomiting, heartburn, and abdominal pain. For example, at doses of 30 mg/kg in schoolchildren there was stomachache in some 16% (SED-12, 775), while in a study with 40 mg/ kg 35% of users had abdominal pain (20). 

Praziquantel is a well tolerated and safe drug. However, it may produce some side effects, the most common of which are abdominal pain, nausea, anorexia, diarrhea or loose stools, dizziness, headache, pruritis, skin eruption and fever, which appear shortly after the drug administration [81,83]. These side effects are usually mild and dose related and disappear within 24 hours. Praziquantel has been found to be free of mutagenic, carcinogenic and teratogenic effects [81,83,84]. 

As described earlier, praziquantel is a safe and well tolerated drug with no serious side effects. The typical side effects of the drug are abdominal pain, nausea, diarrhea, headache, skin rash and fever. Rarely praziquantel may cause neuropsychiatric, cardiovascular and dermatological reactions, hepatic changes, delayed fatigue and inability to work. Care should be taken while treating patients with chronic and... 

In an open, randomized comparison of mefloquine (25 mg/kg), artesunate (three doses of 4 mg/kg), artesunate + mefloquine (three doses of artesunate 100 mg+mefloquine 250 mg), and praziquantel (40 mg/kg) in 83 children with Schistosoma haematobium infection, the cure rates at day 26 were 21%, 25%, 61% and 88% respectively [14 ]. Both artesunate + mefloquine and praziquantel achieved egg reduction rates of over 95%. Abdominal pain was the most frequent adverse reaction, with a higher incidence among children treated with mefloquine (89%), mefloquineartesunate (83%), and artesunate (60%) than in those treated with praziquantel (40%). 

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