Abdominal pain loperamide

Loperamide stimulates enteric nervous system receptors, inhibiting peristalsis and fluid secretion. It improves stool consistency and reduces the number of stools.21 Consequently, it is most useful in patients who have diarrhea as a prominent symptom. However, it can occasionally aggravate abdominal pain. 

Irinotecan treatment schedules differ from 125 to 150 mg/m2 once a week for 4 wk followed by a 2-wk drug free interval (United States), to 350 mg/m2 once every 3 wk (Europe), or 100 mg/m2/wk or 150 mg/m2 every 2 wk (Japan). Differing intermittent treatment schedules using cytokine support for neutropenia, or intensive loperamide to counteract diarrhea, have also been reported (14). These tolerable CPT-11 regimens have produced median durations of response that range from 5.6 to 10.6 mo in colorectal patients disease stabilization occurs in 30 to 71 % (40). Response rates of 26% and 32% have been reported for previously untreated colorectal cancer patients higher response rates have been reported for non-5-FU-refractory patients (only 7-21%). Symptoms of diarrhea, nausea, and vomiting are common toxicities other side effects are asthenia, abdominal pain, leukopenia, and neutropenia. In the US trials at least one of these adverse... 

DESMOPRESSIN ANTIDIARRHOEA DRUGS -LOPERAMIDE t desmopressin levels when given orally Delayed intestinal transit time t absorption of desmopressin Watch for early features of desmopressin toxicity (e.g. abdominal pain, headaches)... 

A 57-year-old woman developed severe abdominal pain 2 hours after taking codeine. She had had two similar episodes in the past, once with loperamide and once with codeine. An abdominal CT scan showed edematous acute pancreatitis. 

Loperamide is an opioid whose action is almost completely restricted to the gut. Recognition of its consequent safety, if it is appropriately used, has led to its being released in many countries for sale without prescription. It nevertheless has some central activity, and nausea, dizziness, dry mouth, abdominal pain, ileus, and lethargy all occur in a minority of users, with occasional reports of more serious central reactions, such as a possible association with delirium in a child (1). 

On the la.st day of amoxicillin treatment, site developed diarrhea with some abdominal pain but no vomiting. Initially the stools were alternately watery and solid, but later they became mucoid with some blood. After 11 days of these symptoms, she was given loperamide for her diarrhea, and a stool culture was positive for Clostridium difficile. 

LItovitz T et al Surveillance of loperamide Ingestions an analysis of 216 poison center reports. J Toxicol Clin Tox/co/1997 35(1) 11-19. [PMID 9022646] (Drowsiness, vomiting and abdominal pain were the most frequent symptoms. There were no life-threatening symptoms and no deaths. The authors recommend home observation without decontamination for ingestion of less than 0.4 mg/kg.)... 

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