A Short History of SFC-NMR Coupling

NMR spectroscopy under high-pressure conditions is as old as NMR itself. Benedick and Purcell [13] first utilized a pressure vessel surrounded by an RF coil in 1954, while Jonas and co-workers [14,15] continually developed this approach over some three decades. 

Studies of high-pressure NMR spectra have been carried out in by one of two ways, known, respectively, as the high-pressure probe method and the high-pressure cell method. High-pressure probes usually show a better sensitivity, due to the better filling factor. 

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