A-methyliminodiacetate

Nitrilotriacetate (NTA), A-methyliminodiacetate (MIDA) and iminodiacetate (IDA) (116) form a series of 1 1 and 1 2 (metakligand) complexes with Rh111 (and Co111), which have been characterized by H NMR and electronic spectra.1087 On the basis of the NMR and a comparison to the Co analog,... 

An important application is the use of A-methyliminodiacetic acid (MIDA) esters as protecting groups (4.2.8). These MIDA esters are readily cleaved in mild basic aqueous conditions, but are stable to many standard functional-group transformations, even chromic acid oxidations. 

As part of a study of the exchange reaction between trans(fac)-[Cr(L)2 - ion and free L (L = A-methyliminodiacetate ion), the reaction of [Ci(L)(H20)3]+ ion with L was studied. An intermediate, probably [Cr(L)(HL)(H20)], is involved in the exchange and anation reactions, where HL is co-ordinated as a bidentate ligand through a N and one COj- group and with one unco-ordinated carboxylate group protonated. ... 

Complexing of the reductant also induces rate enhancement of cobalt(ni) complexes. The rate constant for reduction of [Co(NH3)60Ac] + by iron(n) has been given a lower limit of 5 x 10 1 mol s whereas when the reductant is complexed to A-methyliminodiacetate (L ) in glycine buffer the corresponding value is 1.52 x 1()- 1 mol s. The rate law derived is... 

Discussion. This method is based upon the formation of a fluorescent chelate between calcium ions and calcein [fluorescein bis(methyliminodiacetic acid)] in alkaline solution.29 The procedure described below30 has been employed for the determination of calcium in biological materials.31 ... 

Products of substitution of inosine and guanosine 5 -monophosphate for chloride or for water on ternary aminocarboxylate complexes such as [Pd(mida)(D20)], where mida = IV-methyliminodiacetate, or [Pd2(hdta)Cl2]2-, where hdta = 1,6-hexanediamine-A(7V,./V,./V,-tetraace-tate, is subject to mechanistic controls in terms of number of coordinated donor atoms and pendant groups and of the length of the chain joining the functional groups in the bis-iminodiacetate ligands. These factors determine the nature and stereochemistry of intermediates and the relative amounts of mono- and bi-nuclear products (253). 

Methylidine chloride, 6 249 Methylidyne complex, 26 949 Methyliminodiacetic acid (MIDA), 19 265 Methyl iodide, 14 376 Methyl ionone, 3 232 a-iso-Methylionone, 24 562, 566 a-n-Methylionone, 24 565 p-iso-Methylionone, 24 566 P-n-Methylionone, 24 565 Methyl isoamyl ketone (MIAK),... 

Methyliminodiacetate and glycinate 01 tryptophan ( + )-,( — )-,or ( )-1,2-Diaminocyclopentanetetra-acetate DL-2-Amino-4-hydroxybutyric acid NiV -Ethylenediamine bis-(a-glutaric acid) ds,cis-l,3,5-Triaminocyclohexane-NN N"-triacetate iV-jff-Hydroxyethylpropylenediamine... 

The behaviour in solution of dimethyltin(IV) complexes containing different aminopoly-carboxylic acids were also investigated293,294. The X-ray crystal structure analyses of the tin complexes with IV-methyliminodiacetate (mida), pyridine-2,6-dicarboxylate (pdc) and ethylenediamine-iV.iV -di acetate (edda) revealed dimeric structures for the first two compounds and a monomeric structure for the complex dimethyltin (edda). In contrast, the dimethyltin(IV) complex (137) with ethylcncdiarninc-/V,/V,iV, /V -tetraacetate (edta) and water is a polymer in which each tin atom adopts a distorted pentagonal-bipyramidal configuration with the two methyl groups in axial positions. 

Phosphates, phosphonates, EDTA, DTP A and methyliminodiacetic acid for the evaluation of renal function. Gluconate, glucoheptonate, ascorbate, insulin and dimercaptosucdnate to image kidney structure261. 

The solution stabilities of the rare earth complexes with N-methyliminodiacetic acid, N-henzyliminodiacetic acid, N-phenyliminodiacetic acid, N-methoxyethyliminodiacetic acid, and N-methylmercaptoethyliminodiacetic acid have been measured at 25°C. and /x = 0.1 (KNOj). The linear relationship between the pk values for the ionization of the ammonium proton and the log Kj values for terdentate iminodiacetate ligands is demonstrated. This relationship is used to provide a measure of the free energy of formation of the third chelate ring in quadridentate iminodiacetates. 

There have been several studies of the interaction of aminopolycarboxylic adds with V ". The rate of reaction of pervanadyl ion with ethylenediamine-JVN -diacetic acid (edda) is ca. 1000 times greater than that with JV-methyliminodiacetic acid (mida) or nitriloacetic acid (nta). This difference is attributed to the occurrence of edda in a monoprotonated form under the reaction conditions, whereas both mida and nta have their single nitrogen atom protonated. The acid nta (H3L) forms V02L in acidic SM-NaClO, the formation reaction being characterized by log K = —0.07 + 0.10. The kinetics of formation have also been measured, as have those of the V -hydroxyethylenediaminetriacetic acid. ... 

There are difficulties associated with the use of ordinary electronic absorption spectra of lanthanide complexes in solution to provide detailed information regarding coordination number and geometry. However, difference spectra versus NdQs are reported for Nd " -ligand (L) solutions for the hn Gsn., transitions (L = dipicolinate, oxydiacetate, iminodiacet-ate, malate, methyliminodiacetate and 7V,A -ethylenebis JV-(o-hych-oxyphenyl)glycinate ). Hypersensitive behaviour was examined and transition dipole strengths were discussed in terms of the nature of the complex species present." ... 

Two years after Stoltz 138) total synthesis of (—)-aurantioclavme (( )-176) (Scheme 4.1), Ellman and co-workers found a way to produce the enantiomerically pure natural product in six steps in 27% overall yield using a newly developed Rh (l)-catalyzed addition of iV-methyliminodiacetic acid (MIDA) boronate 198... 

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