A hyperglycemia

Lindenmayer JP, Smith RC, Singh A, Parker B, Chou E, Kotsaftis A. Hyperglycemia in patients with schizophrenia who are treated with olanzapine. J Clin Psychopharmacol 2001 21(3) 351-3. 

Uysal K, Uguz A, Olgun N, Sariahoglu F, Buyukgebiz A. Hyperglycemia and acute parotitis related to L-asparaginase therapy. J Pediatr Endocrinol Metab 1996 9(6) 627-9. 

A. Hyperglycemia. Administer regular Insulin 5-10 U IV initially, followed by Infusion of 5-10 U/h, while monitoring the effect on serum glucose levels (children administer 0.1 U/kg initially and 0.1 U/kg/h). 

Biologica.1 Activities a.ndAna.logues, The many pharmacological actions of neurotensin include hypotension, increased vascular permeabihty, hyperglycemia, increased intestinal motility, and inhibition of gastric acid secretion (120). In the brain, it produces analgesia at remarkably low doses (121). 

The classic experiments of Von Meting and Minkowski in 1889 first impHcated the pancreas in regulating blood glucose levels removal of a dog s pancreas led directly to the development of hyperglycemia. Then in the early 1920s it was shown that an internal secretion of the pancreas could be isolated... 

CCK is found in the digestive tract and the central and peripheral nervous systems. In the brain, CCK coexists with DA. In the peripheral nervous system, the two principal physiological actions of CCK are stimulation of gaU. bladder contraction and pancreatic enzyme secretion. CCK also stimulates glucose and amino acid transport, protein and DNA synthesis, and pancreatic hormone secretion. In the CNS, CCK induces hypothermia, analgesia, hyperglycemia, stimulation of pituitary hormone release, and a decrease in exploratory behavior. The CCK family of neuropeptides has been impHcated in anxiety and panic disorders, psychoses, satiety, and gastric acid and pancreatic enzyme secretions. 

In long-term treatment, the thia2ides may produce hypokalemia, hyperglycemia, hypemricemia, and a 5% increase in plasma cholesterol indapamide has been shown not to increase plasma cholesterol or Hpids at therapeutic doses (21—23). The decrease of plasma potassium, ie, hypokalemic effect, is dose-dependent, and can be avoided if high doses are avoided (24,25). Thia2ides can cause hyponatremia in patients with large water intake while on the dmg (26,27) hyponatremia may be associated with nausea, vomiting, and headaches. 

Chen et al. state that dendrobine produces moderate hyperglycemia, diminishes cardiac activity in large doses, lowers blood pressure, depresses respiration, inhibits isolated rabbit intestine and contracts isolated guinea-pig uterus. It has a weak analgesic, antipyretic action. Chen and Rose found that the convulsions induced by injection of dendrobine can be controlled by use of sodium isoamylethylbarbiturate they appear to be central in origin due to action on the cord and medulla. 

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