A Halogenocarboxylic

Most of the reactions and properties of 1-substituted imidazoles have been discussed earlier in this review. Apart from the utilization of the readily removable benzyl substituent in synthetic procedures leading to 2-substituted imidazoles, perhaps the mostexciting advances have stemmed from the reactions of the 1 -acylimidazoles (imidazolides) which are extremely reactive in such nucleophilic reactions as hydrolysis and alcoholysis.12 The use of such compounds as N,N -carbonyl-diimidazole in peptide synthesis is now commonplace. The silicon-nitrogen bond in N-trimethylsilylimidazoles is also extremely reactive, so reactive that it is attacked by a-halogenocarboxylic esters.361... [Pg.183]

Via intermediates Phenols from hydrocarbons via amines s. 1,192 a-Hydroxy ketones from ketones via a-isonitrosoketones s. 2,145 a-Hydroxycarboxylic acids from carboxylic acids via a-halogenocarboxylic acids s. 1,451 v.l. H —OH... [Pg.48]

Potassium hydroxide a-Hydroxycarboxylic acids from a-halogenocarboxylic acids... [Pg.76]

Darzens-Claisen reaction Glycidic acid esters from a-halogenocarboxylic acid esters and oxo coumpounds... [Pg.474]

Reactions of alkylidenephosphoranes with

halogenocarboxylic acid esters... [Pg.499]

Ketenes from a-halogenocarboxylic acid halides CHalCOHal -> C C O... [Pg.574]

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