A catenin

Genetic Familial prostate cancer is inherited in an autosomal dominant manner. Mutations in p53, Rb, E-cahedrin, a-catenin, androgen receptor, KAII, microsatellite instability, loss of heterozygocity at 1, 2q, 12p, 15q, 16p, and 16q. Candidate prostate cancer gene locus identified on chromosome 1. 

Vermeulen, S., Bruyneel, E-, Brackc, M., Bmyne, G., fennekens, K-, Vleminckx, K., Berx, G., Roy, EM., and Mareel, M. M. (1995), Transition from the nonin vast ve to the invasive phenotype and loss of a-catenin in human colon cancer cells. Cancer Res. S5,4722-4728,... 

Cell adhesion and motility E-Cadherin, a, -Catenin, FAK, Cadherin5, P-Se-lectin, ICAMs, LIMK1,2, pl30CAS, Integrins, PECAM, Paxillin, Talin, Calpain, FAK, Vincullin, Src, CSK, Actin stress fibers Peripheral vascular disease. Cancer... 

Fig. 18.12. A. Catenins and cadherins. E-cad-herin molecules form intercellular, calcium-dependent homodimers with cadherins from another cell, resulting in cell-cell adhesion. The cytoplasmic portion of E-cadherin is com-plexed to a variety of catenins, which anchor the cadherin to the actin cytoskeleton. B. (3-Catenin and APC in transcription. The APC complex activates (3-catenin for proteolytic degradation. If APC is inactivated, (3-catenin levels increase. It acts as a transcription factor that increases synthesis of myc and other genes regulating cell cycle progression.

FIGURE 34.2 Illustration of cadherin receptors associated with actin cytoskeleton. Cadherin dimers are shown in a linear zipper structure with antiparallel binding of the ECl domains. Cytopiasmic taiis of cadherins interact with actin filaments through structural proteins -catenin, pl20 catenin, plakoglobin, and a-catenin. 

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