9H-fluorenes

FLUORINECOMPOUNDS,ORGANIC - FLUOROETTiERS AND FLUOROAMINES] (Vol 11) 4(9H-Fluoren-9-ylidenemethyl)-N,N-bis(methylphenyl)benzenamine [ql[115838-15-8]... 

Piperidinedicarboxylic acid, 4-[ [(9H-fluoren-9-ylmethyloxy)carbonyl] amino]-... 

To a 50-mL polypropylene vial (Note 1) are added 0.839 g (2.67 mmol) of 2-[ethyl[4-[(lE)-(4-nitrophenyl)azo]phenyl]amino]ethanol (Disperse Red 1, Note 2), 0.985 g of (2.39 mmol) N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-aspartic acid,l-(l, 1-dimethylethyl) ester (Fmoc-L-Asp-OtBu, Note 3), 3.26 g (4.73 mmol) of polystyrylsulfonyl chloride resin (Note 4), and 30 mL anhydrous methylene chloride (Note 5). The vial is capped and the mixture is shaken for five min (Note 6). N-Methylimidazole (0.764 mL, 9.58 mmol) is then added to the deep red mixture (Note 7) and the resulting mixture is shaken for 2 hr (Note 8). 

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-aspartic acid, l-(l,l-dimethylethyl) ester L-Aspartic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, l-(l,l-dimethylethyl ester (129460-09-9). 

Selective transformations Selective styrene ring opening [103] One-pot domino process for regioselective synthesis of a-carbonyl furans [104] Tandem process for synthesis of quinoxalines [105] Atmospheric oxidation of toluene [106] Cyclohexane oxidation [107] Synthesis of imines from alcohols [108] Synthesis of 2-aminodiphenylamine [109] 9H-Fluorene oxidation [110] Dehydrogenation of ethane in the presence of C02 [111] Decomposition of methane [112] Carbon monoxide oxidation [113]... 

Kumar, R., Garces, L.J., Son, Y., Suib, S.L. and Malz, R.E. (2005) Manganese oxide octahedral molecular sieve catalysts for synthesis of 2-aminodiphenylamine. Journal of Catalysis, 236, 387-391. Opembe, N.N., Son, Y., Sriskandakumar, T. and Suib, S.L. (2008) Kinetics and mechanism of 9H-fluorene oxidation catalyzed by manganese oxide octahedral molecular sieves. ChemSusChem, 1, 182-185. 

Finally, Larock and coworkers [34] recently reported on an efficient synthesis of 9-alkylidene- and 9-benzylidene-9H-fluorenes 6/1-47, again using 6/1-42 and 6/1-43 as substrates. The best results were obtained with sodium acetate and Bu4NC1, which allowed 6/1-47 to be obtained in 62 % yield. A proposed mechanism is given in Scheme 6/1.9, suggesting a migration of palladium from a vinylic to an arylic position [35]. 

S)-N-(9-PHENYLFLUOREN-9-YL) ALANINE AND (S)-DIMETHYL N-(9-PHEN YLFLU0REN-9-YL)ASPARTATE L-Alanlne, N-(9-phenyl-9H-fluoren-9-yl)- and L-Aspartic acid, N-(9-phenyl-9H-fluoren-9-yl>, dimethyl ester)... 

Bromo-9-phenylfluorene 9H-Fluorene, 9-bromo-9-phenyl- (9) (55135-66-5) Butyllithium, lithium, butyl- (8,9) (109-72-8)... 

Bromo-9-phenylfluorene 9H-Fluorene, 9-bromo-9-phenyl (9) (55135-66-5) (S)-Dimethyl aspartate hydrochloride Aspartic add, dimethyl ester, hydrochloride, L- (8) L-Aspartic acid, dimethyl ester, hydrochloride (9) (32213-95-9) 9-Methoxy-9-phenylfluorene 9H-Fluorene, 9-methoxy-9-phenyl- (9) (56849-87-7) 9-Phenyl-9-fluorenol Fluoren-9-ol, 9-phenyl- (8) 9H-Fluoren-9-ol, 9-phenyl- (9) (25603-67-2)... 

Lopez-Rodriguez, M.L., Morcillo, M.J., Rovat, T.K., Fernandez, E., Vicente, B., Sanz, A.M., Hernandez, M. and Orensanz, L. (1999) Synthesis and structure-activity relationships of a new model of arylpiperazines. 4.1-[o-(4-Arylpiperazin-l-yl)alkyl]-3-di-phenylmethylene-2,5-pyrrolidinediones and -3-(9H-fluoren-9-ylidene)-2,5-pyrrolidinediones study of the steric requirements of the terminal amide fragment on 5-HTiA affinity/selectivity. Journal of Medicinal Chemistry, 42,36—49. 

One case of n—5 —n delocalization was demonstrated by Stevenson et al. (2006). The potassinm anion-radical salt of l-(9-methyl-9H-fluoren-9-yl)-4-methyl benzyl is characterized by the delocalization of an nnpaired electron within the fluorenyl moiety only. Its ESR spectrnm completely coincides with the spectrnm of the potassium anion-radical salt of the 9,9-dimethyl fluorene anion-radical in THE However, the cesium anion-radical salt of the fluorenyl methylbenzyl derivative produces the ESR spectrum corresponding to the placement of this cation between the fluorenyl and methylbenzyl moiety. The conditions of n—s—n delocalization appear An unpaired electron spends its time within both fluorenyl and methylbenzyl fragments. The situation is explained in Scheme 3.54. 

For ketones in which a CH2 group is replaced by a C=0, one adds the suffix one. For example, 9H-fluorene (XXII) becomes 9//-fluoren-9-one or 9-fluorenone (XXIII). 

Enzymatic Resolution of /V-Acetyl-3-(9-oxo-9H-fluoren-3-yl)alanine (82) To Give (2S)-3-(9-Oxo-9H-fluoren-3-yl)alanine [(S)-69] and (2/ )-A-Acetyl-3-(9-oxo-9H-fluoren-3-yl)alanine [(R)-82] [153l... 

The first example of the use of a chiral-core dendrimer as enantioselective receptor in molecular recognition processes was reported by Diederich (see Fig. 4.70). This dendrimer, designated as a dendrocleff, acts as enantioselective receptor for monosaccharides. It bears a central axially chiral 9,9 -spirobi[9H-fluorene] unit which is linked via two 2,6-bis(carbonylamino)pyridine spacer groups, each in 2,2 position, with triethylene glycol monomethyl ether dendrons [14b]. Both... 

Chemical Name 1,6-Hexanediaminium, N,N -di-9H-fluoren-9-yl-N,N,N, N -tetramethyl-, dibromide... 

Tilorone hydrochloride, 2,7—bis [2-(diethylamine) ethoxy]-9H-fluorene-9-one dihydrochloride, is an orange solid which is highly water soluble at neutral and acidic pH. The compound is anhydrous and melts between 234-234.5 °C with decomposition. The molecular weight is 483.47. Tilorone-HC1 has an intense absorption band at 270 nm in water. The pKa of the amine functions are 8.64 and 9.27, respectively the compound is stable in acid or base. The synthesis of tilorone hydrochloride was outlined by Andrews et al.10), and Gaur and Wacker15). 

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