64Cu

Cu is produced via a proton reaction on enriched 64Ni, followed by separation from the 64Ni target ... 

Cu is unusual in that it undergoes three types of decay ft, electron capture and j3+ leading to particulate emissions for therapy and gamma rays for imaging. 

A number of novel dioxo variants of the tetraazamacrocycles have been synthesized and stability constants were measured with Cu2+.114 A few of these were further evaluated as chelating agents with 64Cu.115 Structural differences included ring size (from 12 to 14) and placement of the oxo groups. Of the six variations synthesized, only one, l,4,8,ll-tetraazacyclotetradecane-3-9-dione(14N402-3,9), readily formed a complex (Figure 9). 

An early account194 describes an attempt to use 64Cu complexes of haematoporphyrin, protoporphyrin, uroporphyrin, and coproporphyrin to detect tumors preferential localization in tumors was not observed. It needs to be recognized that metalation can change solution... 

In some cases, a nuclide may undergo decay by more than one process at the same time. For example, 64Cu undergoes decay by three processes simultaneously ... 

The overall rate of disappearance of 64Cu is the sum of three processes, but by making use of different types of counting methods, it is possible to separate the rates of the processes. 

Other advantages of PET imaging with metallic radionuclides are facile radiolabeling (i.e. certain 64Cu complexes radiolabel in less than lmin at room temperature (12)) and generator availability (for 68Ga). 

Fig. 33. PET imaging of mice tumor after administration of compounds A and B respectively. Top images show regional concentration uptake of the folate-targeted (A) or nontargeted (B) 64Cu radiotracers. Figure adapted from Ref. (153).

The 0.001M CuCl2 solution labelled by 64Cu and K2Cr207 solution (pH 2) labelled by 51Cr were used to find out the best technology of... 

Cl) samples were irradiated in a reactor with thermal neutron flux of 6 X 1013 neutrons/cm2/sec for 2 secs and counted with a large volume Ge(Li) detector. 3 samples of 10 mg each were used. For longer lived isotopes (Cu, Sn, Co, Ag, Au, and Sb) samples were irradiated for 1 hr, cooled for 7 days, diss. in HN03-HF and made up to standard volume for counting. Pure metal foil standards were used for Cu, Sn, Co, Au pure NH4C1 was used for Cl and pure Sb3 for Sb. In calculated from intensity of 116mIn, 1.26 Mev 7 relative to 64Cu 1.34 Mev 7. 

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