Zn-binding domains

Zn-binding domain, present in CBP/p300 and Dystrophin. In Dystrophin, domain is implicated in Calmodulin binding. Mis-sense mutation of conserved cysteine correlates with Duchenne muscular dystrophy. 

Description (CD ID) Consensus Function Examples in RING proteins (Cenebank Accession) Zn-binding domain R rences... 

Chuang LS, Ng HH, Chia JN, Li BF. Characterisation of independent DNA and multiple Zn-binding domains at the N terminus of human DNA-(cyto-sine-5) methyltransferase modulating the property of a DNA-binding domain by contiguous Zn-binding motifs. J Mol Biol 1996 257 935-948. 

Bprresen-Dale, A.-L., Lothe, R., Meling, G., Hainaut, P., Rognum, T., and Skovlund, E. (1997) TP53 and long-term prognosis in colorectal cancer mutations in the L3 Zn-binding domain predict poor survival. Clin. Cancer Res. 4,203-210. 

Structural information is available for the J domains of E. coli DnaJ, human DjBl/Hdj-1, and polyomavirus T-antigen (Szyperski et al., 1994 Pellecchia et al., 1996 Qian et al., 1996 Beijanskii et al., 2000 see Section III.B.2.b), the Zn-binding domain of E. coli DnaJ (residues 121— 209 Martinez-Yamout et al., 2000), and the C-terminal domain of yeast Sisl (residues 171-352) which has homology to the C-terminal domain... 

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