Zerumbone structure

Further research on terpenoid plant growth regulators has shown that cross-conjugated dienones such as zerumbone (288), epoxyzerumbone (289), and santonin (290) display root-promoting activity whereas related compounds (291)—(293) devoid of this structural feature do not. Molecular mechanics... 

Zerumbone, from Zingiber zerumbet, was shown to effectively suppress free radical generation, pro-inflammatory protein production, and cancer cell proliferation while additionally inducing the apoptosis of these same cells. An analysis of the relationship between the compound s structure and its activity indicated that the a, (5-unsaturated carbonyl group in the sesquiterpene structure is a requisite for the compound s... 

Several monoterpenes [320,321], humulene (364) [320] and zerumbone (365) [322] have been reported from the essential oil from the rhizomes of Zingiber zerumbet. The characterization and elucidation of structure 365 of zerumbone was reported later [323]. The crystal structure of zerumbone isolated from the rhizomes of Z. zerumbet was determined by single-crystal X-ray diffraction [324]. The stereochemistry of the double bonds of humulene was established by crystallographic study of its silver nitrate adduct [325, 326]. The essential oil from the rhizomes of Z. 

---