Zametkin, Alan

Zametkin, Alan J., et al. Cerebral Glucose Metabolism in Adults with Hyperactivity of Childhood Onset. New England Journal of Medicine 323 (1990) 1361-1366. 

Zametkin, Alan ]., Laura L. Liebenauer, et al. Brain Metabolism in Teenagers with Attention-Deficit Hyperactivity Disorder. Archives of General... 

A study led by NIMH s Alan Zametkin et al. (1990) received a great deal of publicity for finding increased brain metabolism in PET scans of adults with a history of ADHD in childhood. However, when the sexes were compared separately, there was no statistically significant difference between the controls and ADHD adults. To achieve significance, the data were lumped together to include a disproportionate number of women in the controls. In addition, when individual areas of the brain were compared between controls and ADHD adults, no differences were found. It is usually possible to massage data to produce some sort of statistical result, and Zametkin et al. s study is a classic illustration. 

---