Zafirlukast toxicity

ASPIRIN LEUKOTRIENE ANTAGONISTS t levels of zafirlukast Uncertain Watch for early features of zafirlukast toxicity. Monitor FBC and liver function closely... 

Of these agents, zileuton is the least prescribed because of reports of occasional liver toxicity. The receptor antagonists appear to have little toxicity. Reports of Churg-Strauss syndrome (a systemic vasculitis accompanied by worsening asthma, pulmonary infiltrates, and eosinophilia) appear to have been coincidental, with the syndrome unmasked by the reduction in prednisone dosage made possible by the addition of zafirlukast or montelukast. Of these two, montelukast is the most prescribed, probably because it can be taken without regard to meals and because of the convenience of once-daily treatment. 

Montelukast, zafirlukast Block leukotriene D4 receptors Block airway response to exercise and antigen challenge Prophylaxis of asthma, especially in children and in aspirin-induced asthma Oral duration hours Toxicity Minimal... 

THEOPHYLLINE LEUKOTRIENE RECEPTOR ANTAGONISTS -ZAFIRLUKAST Possibly t theophylline levels. Also possibly 4 zafirlukast levels Mutual alteration of metabolism Be aware watch for features of theophylline toxicity and measure levels... 

This class of drugs is not indicated for rapid bronchodilator therapy thus, patients are instructed to have short-acting f adrenergic receptor agonists available as rescue medication. Montelukast and zafirlukast are effective with once- or twice-daily treatment, respectively. In contrast, zileuton is taken 4 times a day. Hepatic transaminases should be monitored in patients beginning zileuton therapy to guard against the potential of liver toxicity. 

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