Yukiyasu Chounan Yoshinori Yamamoto Abstract

Applications of organocopper reagents and reactions to natural product synthesis are classified by reaction type conjugate addition, Sn2 substitution, Sn2 substitution, 1,2-metalate rearrangement, and carbocupration. 

Conjugate addition [2] to Michael acceptors is the most important and useful reaction in organocopper chemistry, and the reaction is often used as the key step in the synthesis of numerous natural and unnatural products. Perhaps one of the most efficient methods for the synthesis of quaternary carbon centers is organo-copper-mediated conjugate addition to /I, yS-disubstituted enones. 

Conjugate addition of organocopper reagents has also been used to introduce multifunctional groups in the final carbon-carbon bond-forming step. The immunosuppressant FK-506 (25) [17] was noteworthy in its activity, which was found 

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