YG Globulin

Yl. Yeung, C. Y., and Hobbs, J. R., Serum yG-globulin levels in normal, premature, post-mature, and small-for-dates newborn babies. Lancet i, 1167-1170 (1968). 

Proteolytic dissection has contributed substantially to our knowledge of the structure and function of the y-globulins. The yG-immunoglobulins constitute the largest portion, about 80% or more, of the y-globulin system and have MW of about 160,000. The molecules are elongated, about 235 X 44 A. A major advance in understanding the structure and... 

Figure 12. Schematic structure of human yG-immuno-globulin molecule. The hinged region attacked by papain is indicated by the diagonal lines.

Figure 13. Schematic structure of human yM-immunoglobulin molecule. The heavy lines between each yG-immuno-globulin like subunit, as well as within each subunit, represent disulfide bonds.

In further trials in turkey poults (50), inclusion of AFBj in the diet at 0.5 yg/g reduced leukocyte counts as well as serum complement titers. Also, serum Y globulins increased during the AFBj exposure period. Toxic effects were diminished by the addition of 2 yg/g Selenium (Se) in the diet (50). Selenium, at concentrations that increased liver glutathione peroxidase (GSH.Px) actvity, probably detoxified the AFBj[ 2,3 oxide... 

Leukophilic y-globulin predominantly yG-globu-lin and minor amounts of yA-globulin and yM-globu-lin, which coat the surface of the leukocyte membrane. See Tuftsin. 

Blix, Tiselius and Svensson (16) studied the lipid content of deotro-phoretically separated albumin and a-, p-, and yg obulins from human serum. The lipid was associated chiefly witii the a- and /3-globulin fractions. ... 

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