Y-phenylvaleric acid

Methyl-l-tetralone has been prepared from y-phenylvaleric acid and sulfuric acid 8 and from y-phenylvaleryl chloride and aluminum chloride.9-10 Its preparation from y-valerolactone has not been described elsewhere. 

This compound is most easily named by treating the phenyl group as a substituent. The phenyl group is bonded to carbon-4 (or the y-carbon, in the common system of nomenclature). The parent compoimd is pentanoic acid (valeric acid in the common system). Hence the name of this compound is 4-phenylpentanoic acid or y-phenylvaleric acid. 

Deuterio compounds. -Ethyl-) -(3-thianaphthenyl) propionic acid heated on a steam bath with 10 parts Ni,Al-alloy and 10 parts Na-methoxide in deuterium oxide a-ethyl-y,d,d-trideuterio-y-phenylvaleric acid. Y 70-95%. F. e., also non-... 

The following acids are formed in similar manner and yield by hydrolysis of the corresponding nitriles (p. 252) a-phenylvaleric acid, m.p. 51° and a-phenyl-y-methylvaleric acid, m.p. 78-79°. 

Fig. 8.4. Profiles of the heat effect observed for complexation reactions of y-CyD with (a) 4-phenylbutyric acid, (b) 5-phenylvaleric acid, and (c) 6-phenylhexanoic acid under comparable experimental conditions 2.7-2.9 mM y-CyD and 190-230 mM guest in the initial solutions).

Kim, Y. B., Lenz, R. W., and Fuller,R. C., 1991, Preparation and characterization of poly(P-hydroxyalkanoates) obtained from Pseudomonas oleovorans grown with mixtures of 5-phenylvaleric acid and n-alkanoic acids. Macromolecules 24 5256... 

Figure 4. Chromatogram of a mixture of carboxylic acids as the t-butyidimethylsilyl derivatives. GC conditions DB-1 fused-silica capillary column (30 m x 0.32 mm i.d, 0.25 pm), initially at 60 "C for 2 min, then programmed to 280 °C at 4°C/min 0.8 pi sample, injected with split ratio of 15 1 both injector and detector temperatures at 300 °C nitrogen as the carrier gas at 0.9ml/min. Peaks l = formic, 2 = acetic, 3 = propionic, 4 = isobutyric, 5 = butyric, 6 — isovaleric, 7 = valeric, 8 = caproic. 9 = enanthic, 10 = benzoic, 11= caprylic, 12 = lactic, 13 = phenylacetic, 14 = glycollic, 15 = oxalic, 16 = pelargonic. 17 = malonic, 18 = capric, 19 - succinic, 20 - methylsuccinic, 21 = undecanoic, 22 = fumaric, 23 = 5-phenylvaleric, 24 = p-aminobenzoic, 25 = lauric. 26 = mandelic, 27 = adipic, 28 = 3-methyladipic, 29 = tridecanoic, 30 = phenyllactic. 31 = hippuric, 32 = myristic, 33 = p-hydroxybenzoic, 34 = malic, 35 = suberic, 36 = pentadecanoic, 37 = vanillic, 38 = palmitic. 39 = syiingic, 40 = tartaric, 41 — margaric, 42 = a-resorcylic, 43 = p-hydroxymandelic, 44 = y-resorcylic, 45 = stearic. 46 = homogentisic, 47 = protocatechuic 48 = nonadecanoic, 49 = citric 50 = cirachidic acid. (Reproduced from Ref. 299 with permission).

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