Y<?-mcthyl-

Gancidovir. Ganciclovir, 9-l(l.3-diliydroxy-2-propox-y)mcthyl guaninc) or DHPG (Cytovcnc). is an analogue of acyclovir, with an additional hydroxymethyl group on the acyclic side chain. 

Examples of the two macromolecular nomenclature systems are as follows. For source-based names for homopolymers and copolymers polyacrylonitrile, poly(mcthyl methacrylate), polylacrylamidc-co-vinylpynolidinone), polybutadiene-felocJ-polystyrene, and poly(propyl methacrylate)-gra/t-poly( 1-vinylnaphthalene). Structure-based examples arc as follows polyloxy-l,4-phcnylcnct (1), po]y(oxycthyl-cncoxytcrcph-thaloy) (2) and poly[imino(l-oxo-l,6-hexanediyl)J (3). 

AMI molecular orbital studies of gas-phase deprotonations of /V-mcthyl-4-(Y-phenylsulfonylmethyl)pyridinium cations and /Y-(Y-benzyl)-4-(phcnylsulfonylmcthyl)-pyridinium cations promoted by NH3 reveal negative transition state imbalances, I (= a — P) < 0 (where a = 0.17-0.18 and p = 0.53), which are a consequence of the difference in distance between the substituents and the anionic charge centre in the transition state and products.149... 

Levites Y, Weinreb O, Maor G, Youdim MB, Mandel S. 2001. Green tea polyphenol (—)-epigallocatechin-3-gallate prevents N-mcthyl-4-phcnyl-l, 2,3,6-tctrahydropyri-dine-induced dopaminergic neurodegeneration. J Neurochem 78 1073-1082. 

Reaction of 2 equiv of 2-aminopyridines with 2-hydropolyfluoroalk-2-anoates 351 in MeCN in the presence of NEt3 at 90 °C for 50 h afforded a mixture of the isomeric 2-oxo-2H- and 4-oxo-4f/-pyrido[l,2-a]pyrimidines 110 and 111. Reaction of 3 equiv of 2-amino-pyridines and 2-hydropoly-fluoroalk-2-enoates 351 in MeCN in the presence K2C03 could be accelerated by ultrasonic irradiation (125 W). 2-Amino-6-methylpyridine yielded only 2-substituted 6-mcthyl-4//-pyrido[l,2-a]pyrimidin-4-oncs 111 (R = 6-Me), whereas 2-amino-5-bromopyridine gave a mixture of 7-bromo-4//-p y ri d o [ 1,2 - a ] p y ri m i d i n -4- o n c (111, R = 7-Br, Rf = CF2C1) and 2-(chlor-o,difluoromethyl)-6-bromoimidazo[l, 2-<2]pyrimidine-3-carboxylate in 44 and 8% yields, respectively (97JCS(P1)981). Reactions in the presence of K2C03 in MeCN at 90°C for 60h afforded only imidazo[l,2-a]pyrimidine-3-carboxylates. 

CN dimethylcarbamic acid 7-chloro-2,3-dihydro-l-mcthyl-2-oxo-5-phenyl-l//-l 4-benzodiazep - y... 

Synthesis ofkarahanaenaue. The ionic reaction of NBS in CCI4 at room temperature with a y-ethylcnic tertiary alcohol leads to an -bromotetrahydrofurane. The reaction has been used in a convenient synthesis of karahanaenone (4), a constituent of hop oil, from linalool (1). Thus reaction of (1) with NBS affords 2-mcthyl-2-vinyl-5-(l-bromo-l-methylethyl)tetrahydrofurane (2) in 85% yield. Dehydrohalogena-tion of (2) with collidine at 110 leads to the allyl vinyl ether (3), which immediately... 

Hu LA, Tang Y, Miller WE, et al. -Adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of pradrenergic receptor interaction with -mcthyl-D-aspartatc receptors. J Biol Chem 2000 275 38,659-38,666. 

A further evidence on the acceleration enjoyed by a typical Pd-catalysed reaction, the Heck reaction, in an ionic phase ( V-mcthyl-Y.Y. V.-trioctylammonium chloride or Aliquat 336) is found in a triphasic protocol developed by Tundo and coworkers. 7b.The arylation of electron poor olefins is catalysed by palladium supported on charcoal (Pd/C) and is carried out in the heterogeneous isooctane/Aliquat 336/water system (Figure 27). Under this multiphasic condition, Aliquat 336 forms a third liquid phase between the organic and the aqueous phase that traps the catalyst. The use of phosphines is not necessary. As a matter of fact, Aliquat 336 incorporates the solid-supported catalyst and ensures an efficient mass transfer between the bulk phases resulting in an increase of the reaction rate of an order of magnitude compared to the reaction in the absence of the ionic liquid. A determing role is played by the base while I LN drives the reaction towards the formation of ethyl cinnamate, reaction carried out in the presence of KOH lead to formation of Ullmann dimerisation products. 

Problem 6.5 Write structural formulas for (a) (/ )-2-mcthyl-3-hexenc (trans), (b) (S)-3-chloro-1 -pentene, (c) (W),(Z)-2-chlor<)-3-heptene (ri.y). 

Bis-[triphenyl-mcthyl]-5-methoxycarbonyl- 512 1 -(9-Bora-bicyclo[3.3.1 ]nonan-9-y l)-3,5-di-tert.-butyl- 601... 

Athyl-benzoyl-amino)-l-liydroxy- 646 2-Xthyl-1 - [hutadicn-( 1,2)-yl J- 270 Amino- 570,1047, 1072, 1120. 1127, 1460, 1464, 1578 2-Atnino-l-acetyl- 993. 1100, 1268, 1312 4-Amino-1-acetyl- 993 2-(2-Amino anilino)-l.3.4-lrimelhyl- 1268 4-Ainino-l,3-dimethoxy- 994 2-Amino-3.5-dimethoxy-l -acetyl- 994 6-Amino-l.5-dimethyl- 1334 2-Amino-5-hydroxy-1 -acetyl- 567. 1269 2 mino-5-hydroxy-l,3-di-tert.-butyl- 1336 2-Amino-5-hydroxy-6-mcthyl-l-acetyl- 567 6-Amino-3-hydroxy methyl-1-acetyl- 567 6-Amino-3-hydro. y-2-mcthyl-l -acetyl- 567 6-Amino-5-[2-hydroxy-propvl-(2)]-l,3-di-lerl.-butvl-1342... 

Ilamycins (Rufomycin) S. islandicus Acid-fast bacteria 1,100 Ala, Leu, Me-Leu, y-formyl-mcthyl-norvaline, 3-nitro-4-hydroxy-Phe, Try, 2-amino-4-hexenoic acid... 

Pyrethrin I, C Hj,03, 2,2 dimethyl-3 (2-methyt-I.pro. penyt)cyclopropanecarboxylic add 2-mcthyl-4-oxt>-3 (2,4-pentadlenytb2 cyclopenten I-y 1 ester, chrysonthemummono-carboxylic acid pyreth rolone ester. R = CH3. Viscous liq-uid. bp,( K 146-150°. 1.5242. [a]g — 14 (isooctane),... 

Kumada Y, Horinouchi S, Uozumi T, Beppu T. Cloning of a streptomycin-production gene directing synthesis of N-mcthyl-L-glucosaminc. Gene 1986 43 221-224-... 

Mctli5d-4.6-diphenvi-pyron-(2) 17 II 411. 3-Mcthyl-2-8tyryl-cIu oinon 17 IT 412. y-p-Tolyl- -benzylidcn-/lPy-crotonlacton... 

Lacton der 2-Mcthyl-4 Q9 oxy d (2>ohlor- phenyl)-a.y-butadienyl]-1.4 ohromen> carbon8aure<(3) 19 II171. 

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